Skip to main content
SpringerLink
Log in

Cholinergic dependence of a cortical neuronal mechanism that supports pavlovian eyeblink conditioning

  • Published:
Neuroscience and Behavioral Physiology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. D. L. Alkon, “Voltage-dependent calcium and potassium ion conductances: a contingency mechanism for an associative learning model,” Science,205, 810–816 (1979).

    PubMed  CAS  Google Scholar 

  2. S. Aou, C. D. Woody, and D. Birt, “Changes in the activity of units of the cat motor cortex with rapid conditioning and extinction of a compound eye blink movement,” J. Neurosci.,12, 549–559 (1992).

    PubMed  CAS  Google Scholar 

  3. S. Aou, C. D. Woody, and D. Birt, “Increases in excitability of neurons of the motor cortex of cats after rapid acquisition of eye blink conditioning,” J. Neurosci.,12, 560–569 (1992).

    PubMed  CAS  Google Scholar 

  4. O. Arancio, E. R. Kandel, and R. D. Hawkins, “cGMP produces long-lasting presynaptic potentiation in hippocampal cell cultures,” Abstr. Soc. Neurosci.,19, 241 (1993).

    Google Scholar 

  5. A. Baranyi, M. B. Szente, and C. D. Woody, “Properties of associative long-lasting potentiation induced by cellular conditioning in the motor cortex of conscious cats,” Neuroscience,42, 321–334 (1991).

    Article  PubMed  CAS  Google Scholar 

  6. L. Bindman, G. Christofi, K. Murphy, A. Nowicky, “Long-term potentiation (LTP) and depression (LTD) in the neocortex and hippocampus: an overview,” in: Aspects of Synaptic Transmission, T. W. Stone (ed.), Taylor and Francis, London (1991), pp. 3–25.

    Google Scholar 

  7. J. F. Brons and C. D. Woody, “Long term changes in excitability of cortical neurons after Pavlovian conditioning and extinction,” J. Neurophysiol.,44, 605–615 (1980).

    PubMed  CAS  Google Scholar 

  8. T. H. Brown, P. F. Chapman, E. W. Kariss, and C. L. Keenan, “Long-term synaptic potentiation,” Science,242, 724–727 (1988).

    PubMed  CAS  Google Scholar 

  9. J. Bures and O. Buresova, “Plastic changes of unit activity based on reinforcing properties of extracellular stimulation of single neurons,” J. Neurophysiol.,30, 98–113 (1967).

    Google Scholar 

  10. D. Collerton, “Cholinergic function and intellectual decline in Alzheimer's disease,” Neuroscience,19, 1–28 (1986).

    Article  PubMed  CAS  Google Scholar 

  11. J. A. Connor and C. F. Stevens, “Voltage clamp studies of a transient outward membrane current in gastropod neural somata,” J. Physiol.,213, 21–30 (1971).

    PubMed  CAS  Google Scholar 

  12. J. A. Deutsch, “The cholinergic synapse and the site of memory,” Science,174, 788–794 (1971).

    PubMed  CAS  Google Scholar 

  13. R. W. Dykes, N. Tremblay, R. A. Warren, and M. F. Bear, “Cholinergic modulation of synaptic plasticity in sensory neocortex,” in: Activation to Acquisition: Functional Aspects of the Basal Forebrain Cholinnergic System, R. T. Richardson (ed.), Birkhauser, Boston (1991), pp. 325–345.

    Google Scholar 

  14. B. Gustaffson, M. Galvan, P. Grafe, and H. Wigstrom, “A transient outward current in a mammalian central neurone blocked by 4-aminopyridine,” Nature,299, 252–254 (1982).

    Article  Google Scholar 

  15. W. Gutman, G. Brozek, and J. Bures, “Cortical representation of conditioned eyeblink in the rabbit studied by a functional ablation technique,” Brain Res.,40, 203–213 (1972).

    Article  Google Scholar 

  16. R. D. Hawkins, E. R. Kandel, and S. A. Siegelbaum, “Learning to modulate transmitter release: themes and variations in synaptic plasticity,” Annu. Rev. Neurosci.,16, 625–665 (1993).

    Article  PubMed  CAS  Google Scholar 

  17. W. R. Holmes and C. D. Woody, “Effects of uniform and nonuniform synaptic ‘activation-distributions’ on the cable properties of modeled cortical pyramidal neurons,” Brain Res.,505, 12–22 (1989).

    Article  PubMed  CAS  Google Scholar 

  18. E. H.-J. Kim, C. D. Woody, and N. E. Berthier, “Rapid acquisition of conditioned eye blink responses in cats following pairing of an auditory CS with glabella tap and hypothalamic stimulation,” J. Neurophysiol.,49, 767–779 (1983).

    PubMed  CAS  Google Scholar 

  19. B. I. Kotlyar and Y. S. Ovtcharenko, “Plasticity reactions of the sensory motor cortex to sound combined with electrophoretic application of acetlycholine,” Zh. Vyssh. Nerv. Deyat.,26, 971–977 (1976).

    CAS  Google Scholar 

  20. K. Krnjevic, “Chemical nature of synaptic transmission in vertebrates,” Physiol. Rev.,54, 418–540 (1974).

    CAS  Google Scholar 

  21. D. J. Krupa, J. K. Thompson, and R. T. Thompson, “Localization of a memory trace in the mammalian brain,” Science,260, 989–991 (1993).

    PubMed  CAS  Google Scholar 

  22. D. A. McCormick, P. E. Guyer, and R. F. Thompson, “Superior cerebellar peduncle lesions selectively abolish the ipsilateral classically conditioned nictitating membrane/eyelid response of the rabbit,” Brain Res.,244, 347–350 (1982).

    Article  PubMed  CAS  Google Scholar 

  23. N. Metherate, N. Tremblay, and R. W. Dykes, “Transient and prolonged effects of acetylcholine on responsiveness of cat somatosensory cortical neurons,” J. Neurophysiol.,59, 1253–1276 (1988).

    PubMed  CAS  Google Scholar 

  24. M. A. Musgrave, B. A. Ballyk, and J. W. Goh, “Coactivation of metabotropic and NMDA receptors is required for LTP induction,” NeuroReport,4, 171–174 (1993).

    PubMed  CAS  Google Scholar 

  25. H. Sakai and C. D. Woody, “Identification of auditory responsive cells in the coronal-pericruciate cortex of awake cats,” J. Neurophysiol.,44, 223–231 (1980).

    PubMed  CAS  Google Scholar 

  26. V. M. Storozhuk, S. F. Ivanova, and A. V. Sanzharovskii, “Involvement of glutamatergic intracortical connections in conditioned reflex activity,” Neurofiziologiya,24, 701–712 (1992).

    CAS  Google Scholar 

  27. V. M. Storozhuk, S. Ph. Ivanova, and V. V. Stezhka, “Analysis of extrathalamic synaptic influences on reactions of sensorimotor cortical neurons during conditioning,” Neuroscience,46, 605–615 (1992).

    Article  PubMed  CAS  Google Scholar 

  28. B. E. Swartz and C. D. Woody, “Correlated effects of acetylcholine and cyclic guanosine monophosphate on membrane properties of mammalian neocortical neurons,” J. Neurobiol.,10, 465–488 (1979).

    Article  PubMed  CAS  Google Scholar 

  29. L. L. Voronin, G. Gerstein, I. E. Kudriashov, and S. V. Ioffe, “Elaboration of a conditioned reflex in a single experiment with simultaneous recording of neural activity,” Brain Res.,92, 385–403 (1975).

    Article  PubMed  CAS  Google Scholar 

  30. X. F. Wang, C. D. Woody, V. Chizhevsky, E. Gruen, and J. Landeira-Fernandez, “The dentate nucleus is a short latency relay of a primary auditory transmission pathway,” NeuroReport,2, 361–364 (1991).

    PubMed  CAS  Google Scholar 

  31. N. Weiner, “Atropine, scopolamine, and related antimuscarinic drugs,” in: The Pharmacological Basis of Theraputics, L. Goodman and A. Gilman (eds.), Macmillan, New York (1980), pp. 120–137.

    Google Scholar 

  32. C. D. Woody, Memory, Learning, and Higher Function: A Cellular View, Springer-Verlag, New York (1982), pp. 146–176.

    Google Scholar 

  33. C. D. Woody, A. Baranyi, M. B. Szente, E. Gruen, W. Holmes, V. Nenov, and G. J. Strecker, “An aminopyridine sensitive, early outward current recordedin vivo in neurons of the precruciate cortex of cats using single electrode voltage clamp techniques,” Brain Res.,480, 72–81 (1989).

    Article  PubMed  CAS  Google Scholar 

  34. C. D. Woody, T. Bartfai, E. Gruen, and A. C. Nairn, “Intracellular injection of cGMP-dependent protein kinase results in increased input resistance in neurons of the mammalian motor cortex,” Brain Res.,386, 379–385 (1986).

    Article  PubMed  CAS  Google Scholar 

  35. C. D. Woody and P. Black-Cleworth, “Differences in excitability of cortical neurons as a function of motor projection in conditioned cats,” J. Neurophysiol.,36, 1104–1116 (1973).

    PubMed  CAS  Google Scholar 

  36. C. D. Woody and G. Brozek, “Changes in evoked responses from facial nucleus of cat with conditioning and extinction of an eye blink,” J. Neurophysiol.,32, 717–726 (1969).

    PubMed  CAS  Google Scholar 

  37. C. D. Woody and J. Engel, Jr., “Changes in unit activity and thresholds to electrical microstimulation at coronalpericruciate cortex of cat with classical conditioning of different facial movements,” J. Neurophysiol.,35, 230–241 (1972).

    PubMed  CAS  Google Scholar 

  38. C. D. Woody and E. Gruen, “Acetylcholine reduces net outward currents measuredin vivo with single electrode voltage clamp techniques in neurons of the motor cortex of cats,” Brain Res.,424, 193–198 (1987).

    Article  PubMed  CAS  Google Scholar 

  39. C. D. Woody and E. Gruen, “Cholinergic and glutamatergic effects on neocortical neurons may support rate as well as development of conditioning,” Prog. Brain. Res.,98, 365–370 (1993).

    PubMed  CAS  Google Scholar 

  40. C. D. Woody, E. Gruen, and D. Birt, “Changes in membrane currents during Pavlovian conditioning of single cortical neurons,” Brain Res.,539, 76–84 (1991).

    Article  PubMed  CAS  Google Scholar 

  41. C. D. Woody, E. Gruen, O. Melamed, and V. Chizhevsky, “Patterns of unit activity in rostral thalamus of cats related to short latency discrimination between different auditory stimuli,” J. Neurosci.,11, 48–58 (1991).

    PubMed  CAS  Google Scholar 

  42. C. D. Woody, E. Gruen, H. Sakai, M. Sakai, and B. Swartz, “Responses of morphologically identified cortical neurons to intracellularly injected cyclic GMP,” Exp. Neurology,91, 580–595 (1986).

    Article  CAS  Google Scholar 

  43. C. D. Woody, J. D. Knispel, T. J. Crow, and P. Black-Cleworth, “Activity and excitability to electrical current of cortical auditory receptive neurons of awake cats as affected by stimulus association,” J. Neurophysiol.,39, 1045–1061 (1976).

    PubMed  CAS  Google Scholar 

  44. C. D. Woody, B. E. Swartz, and E. Gruen, “Effects of acetylcholine and cyclic GMP on input resistance of cortical neurons in awake cats,” Brain Res.,158, 373–395 (1978).

    Article  PubMed  CAS  Google Scholar 

  45. C. D. Woody, N. N. Vassilevsky, and J. Engel, Jr., “Conditioned eyeblink: unit activity at coronal-pericruciate cortex of the cat,” J. Neurophysiol.,33, 851–864 (1970).

    PubMed  CAS  Google Scholar 

  46. C. D. Woody, X. F. Wang, E. Gruen, and J. Landeira-Fernandez, “Unit activity to click CS changes in dorsal cochlear nucleus after conditioning,” NeuroReport,3, 385–388 (1992).

    PubMed  CAS  Google Scholar 

  47. C. D. Woody, X.-F. Wang, and E. Gruen, “Activity to acoustic stimuli increases in ventral cochlear nucleus after stimulus pairing,” NeuroReport,5, 513–515 (1994).

    Article  PubMed  CAS  Google Scholar 

  48. C. D. Woody and P. J. Yarowsky, “Conditioned eye blink using electrical stimulation of coronal-pericruciate cortex as conditional stimulus,” J. Neurophysiol.,35, 242–252 (1972).

    PubMed  CAS  Google Scholar 

  49. C. D. Woody, P. Yarowsky, J. Owens, P. Black-Cleworth, and T. Crow, “Effect of lesions of cortical motor areas on acquisition of eyeblink in cat,” J. Neurophysiol.,37, 385–394 (1974).

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. N. Jahed
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Gruen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. D. Woody
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

UCLA Medical Center, Los Angeles, California 90024. Published in Fiziologicheskii Zhurnal imeni. I. M. Sechenova, Vol. 81, No. 11, pp. 10–17, November, 1995.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jahed, N., Gruen, E. & Woody, C.D. Cholinergic dependence of a cortical neuronal mechanism that supports pavlovian eyeblink conditioning. Neurosci Behav Physiol 27, 592–598 (1997). https://doi.org/10.1007/BF02463908

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02463908

Keywords

Search

Navigation