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Transformed steroids

Communication 81. Preparation of δ1,4-3-ketosteroids employing immobilized bacterial cells

  • Organic and Biological Chemistry
  • Published:
Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

  1. 1.

    It was shown that it is theoretically possible to transform Δ5-3β-hydroxy-, Δ5-3β-acetoxy-, and Δ4-3-ketosteroids to Δ1,4-3-ketosteroids employing the immobilized cells of various species of bacteria.

  2. 2.

    The immobilization of the bacterial cells in polyacrylamide gel reduces the rate of the complete cleavage of the steroids and in this way increases the yield of the 1,2-dehydro compounds.

  3. 3.

    The Δ1,4-3-ketosteroids were obtained in 68–85% yield by employing the immobilized cells ofMycobacterium globiforme 193.

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Literature cited

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Authors and Affiliations

  1. N. D. Zelinskii Institute of Organic Chemistry, Academy of Sciences of the USSR, Moscow

    N. E. Voishvillo, A. V. Kamernitskii, A. Ya. Khaikova, I. G. Leont'ev, V. N. Paukov & L. A. Nakhapetyan

  2. All-Union Scientific Research and Biotechnical Institute, Moscow

    N. E. Voishvillo, A. V. Kamernitskii, A. Ya. Khaikova, I. G. Leont'ev, V. N. Paukov & L. A. Nakhapetyan

Authors
  1. N. E. Voishvillo
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  2. A. V. Kamernitskii
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  3. A. Ya. Khaikova
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  4. I. G. Leont'ev
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  5. V. N. Paukov
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  6. L. A. Nakhapetyan
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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya. No. 6. pp. 1357–1360. June. 1976.

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Voishvillo, N.E., Kamernitskii, A.V., Khaikova, A.Y. et al. Transformed steroids. Russ Chem Bull 25, 1303–1305 (1976). https://doi.org/10.1007/BF00928076

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  • DOI: https://doi.org/10.1007/BF00928076

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