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Approaches to the synthesis of 9α,21-dihydroxy-16α,17α-epoxypregn-4-ene-3,20-diones

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Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Abstract

Various approaches to the synthesis of 16α,17α-epoxypregn-4-ene-9α,21-diol-3,20-dione were studied. A preparative method was found for the synthesis of this compound by the microbiological transformations of 20,20-dimethoxy-16α,17α-epoxypregn-5-ene-3Β,21-diol using Rhodococcus sp. with subsequent removal of the dimethyl acetal protection in 20,20-dimethoxy-16α,17α-epoxypregn-4-ene-9α,21-dio-1-3-one.

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Authors and Affiliations

  1. N. D. Zelinskii Institute of Organic Chemistry, Academy of Sciences of the USSR, Moscow

    N. E. Voishvillo, A. M. Turuta, A. V. Kamernitskii, N. V. Dzhlantiashvili & A. A. Korobov

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  1. N. E. Voishvillo
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  2. A. M. Turuta
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  3. A. V. Kamernitskii
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  4. N. V. Dzhlantiashvili
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  5. A. A. Korobov
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 3, pp. 690–693, March, 1990.

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Voishvillo, N.E., Turuta, A.M., Kamernitskii, A.V. et al. Approaches to the synthesis of 9α,21-dihydroxy-16α,17α-epoxypregn-4-ene-3,20-diones. Russ Chem Bull 39, 610–613 (1990). https://doi.org/10.1007/BF00959595

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  • DOI: https://doi.org/10.1007/BF00959595

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