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Transformed steroids. 189. Synthesis and transformations of 21-hydroxy-5α-H-pregnane 2′,2′-dimethyl-[16α,17α-d]-thioxalanes

  • Organic Chemistry
  • Methods Of Synthesis
  • Published:
Bulletin of the Russian Academy of Sciences, Division of chemical science Aims and scope

Abstract

In a continuation of the research on use of 20-keto-16α,17α-epoxysteroid 20-hydrazones for synthesis of 17-thio analogs of 20-ketosteroid 16α,17α-acetonides [2, 3], we synthesized 5α-H-pregnane-3β,16α,21-trihydroxy-17α-thiol-20-one 16,17-acetonide and found methods for its microbiological dehydrogenation and hydroxylation into Δ4-3-keto-and 9α-hydroxy-Δ4-3-keto derivatives.

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Literature cited

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Authors
  1. N. V. Dzhlantiashvili
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  2. A. M. Turuta
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  3. A. V. Kamernitskii
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  4. N. E. Voishvillo
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  5. A. A. Korobov
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Additional information

See [1] for Communication 188.

N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, 117913 Moscow. Translated from Izvestiya Akademii Nauk, Seriya Khimicheskaya, No. 5, pp. 1182–1186, May, 1992.

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Dzhlantiashvili, N.V., Turuta, A.M., Kamernitskii, A.V. et al. Transformed steroids. 189. Synthesis and transformations of 21-hydroxy-5α-H-pregnane 2′,2′-dimethyl-[16α,17α-d]-thioxalanes. Russ Chem Bull 41, 931–935 (1992). https://doi.org/10.1007/BF00864542

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  • DOI: https://doi.org/10.1007/BF00864542

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