Summary
Addition of L-lysine to cultures ofS. noursei enhanced the production of nourseothricin. The aspartokinase of the wild-type strain was under concerted feedback inhibition by lysine plus threonine but was stimulated by lysine alone. Threonine in the medium increased the synthesis of enzyme. 10% of the mutants resistant to AEC showed a higher specific production of the antibiotic.
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Hänel, F., Friedrich, W., Bormann, E.J. et al. Control of the aspartokinase ofStreptomyces noursei and its AEC-resistant mutants. Biotechnol Lett 7, 557–562 (1985). https://doi.org/10.1007/BF01026445
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DOI: https://doi.org/10.1007/BF01026445