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Antimetabolite-induced increases in the invasive capacity of murine leukaemia L1210 cells

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Abstract

Pretreatment of murine leukaemia L1210 cells with non-lethal concentrations of various antimetabolites increased thein vitro invasive capacity of these cells into monolayers of rat embryo fibroblasts. The increase in invasive capacity was partly correlated with the induced cell cycle arrest. The concomitant increase in cell surface fucosylation and inhibition of invasion with sulphate indicate a role for glycoproteins in this process. Our results suggest that treatment with antimetabolites may lead to a more aggressive phenotype by altering cell surface properties.

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Authors and Affiliations

  1. Department of Medical Chemistry, Faculty of Medicine, Vrije Universiteit, Van der Boechorststraat 7, 1081, BT Amsterdam, The Netherlands

    T. W. De Graaf, G. J. Peters &  W. van Dijk

  2. Department of Oncology, Free University Hospital, Amsterdam, The Netherlands

    G. J. Peters

Authors
  1. T. W. De Graaf
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  2. G. J. Peters
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  3. W. van Dijk
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De Graaf, T.W., Peters, G.J. & van Dijk, W. Antimetabolite-induced increases in the invasive capacity of murine leukaemia L1210 cells. Clin Exp Metast 12, 134–142 (1994). https://doi.org/10.1007/BF01753980

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  • DOI: https://doi.org/10.1007/BF01753980

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