Abstract
Three human hepatitis A virus strains, all of them isolated in Italy but one acquired abroad, were analyzed by T1 - RNAase oligonucleotide mapping and by monoclonal antibody neutralization. The variation among their genomes according to T1 - maps was calculated to be about 9%, thus confirming the poor genomic variation assessed by nucleotide sequencing (1 – 10%). However T1 - maps of these Italian isolates were different from those reported in the literature (Weitz and Siegl, 1985). Neutralization by monoclonal antibody caused a reduction in titres of 2 – 2.5 log10.
This genomic stability, if confirmed, is important with a view to a valuable vaccine.
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Fiore, L., de Paolis, E., Novello, F. et al. Characterization by T1-oligonucleotide fingerprinting of three strains of human hepatitis A virus isolated in Italy. Eur J Epidemiol 6, 29–33 (1990). https://doi.org/10.1007/BF00155545
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DOI: https://doi.org/10.1007/BF00155545