Abstract
β-, and γ-cyclodextrin and heptakis-2,6-di-O-methyl-β-cyclodextrin enhance the nitrosation rate of l-ephedrine if the nitrosation assay procedure (NAP test) is applied. During this reaction with β-cyclodextrin a solid inclusion compound of β-cyclodextrin andN-nitrosoephedrine precipitates. Solubilities and stabilities of inclusion compounds of the cyclodextrins with ephedrine and nitrosoephedrine, respectively, explain especially the catalytic effects of some cyclodextrins on ephedrine.
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Part of the PhD thesis of V. Wedelich, Freie Universität Berlin, 1985.
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Wedelich, V., Mehnert, W. & Frömming, K.H. In vitro nitrosation of ephedrine in the presence of cyclodextrins. Journal of Inclusion Phenomena 5, 621–624 (1987). https://doi.org/10.1007/BF00663002
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DOI: https://doi.org/10.1007/BF00663002