Abstract
Szent-Gyorgyi first suggested that electron transfer in the bulk of biological materials could be significant. Recent evidence in favor of this concept is cited. Electron transfer processes occur at interfaces involving glass, cellulosic, and biological membranes. Electron transfer controls the rate of redox processes at some interfaces.
Biological cells can be represented in terms of fuel cell concepts. They adhere and divide, depending upon their surface charge. If the charge is too high, division leads to metastasis.
The surface electrical charge in biological cells is affected in two ways, corresponding to the electrochemical description of interfaces as polarizable and nonpolarizable. At polarizable interfaces, concepts of adsorption determine the surface charge for a given condition. In non-polarizable interfaces, electrode-kinetic concepts (i.e., the rates of the reactions) are directly related to the surface charge.
Cancer, it is suggested, occurs when the charge is sufficiently repuslive. Carcinogenic substances adsorb upon the cell substances and affect primarily the electrode kinetics, or charge density. The role of DNA is to create genes which produce substances which act as scavengers for materials which adsorb upon and, thus, affect the electrical state of the cell surface.
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References
Bacquerel, A. C. 1867.Compt. Rend. Hebd. Séances Acad. Sci. 64, 919.
Becquerel, A. C. 1877.Compt. Rend. Hebd. Séances Acad. Sci. 85, 169.
Bernstein, J. 1902.Arch. Ges. Physiol. 92, 521.
Berry, M. N. 1980. FEBS Letters. 117, K106.
Bethe, A.; Toropoff, Z. 1964.Z. Phys. Chem. 88, 731.
Bockris, J. O'M,; Srinivasan, S. 1967.Nature 215, 197.
Bockris, J. O'M. 1969.Nature 224, 775.
Bockris, J. O'M.; Reddy, A. K. N. 1977.Modern Electrochemistry, Vol. 2, Plenum Rosetta Edn. Plenum Press, New York.
Bockris, J. O'M.; Tunuli, M. S. 1979.J. Electroanal. Chem. 100, 7.
Braun, F. 1891aAnn. Phys. Chem. 42, 450–64.
Braun, F. 1891b.Ann. Phys. Chem. 44, 473–500.
Cairns, J. 1975 (Nov.).Sci, Am. 233, 64.
Climenthi, W. 1981. Paper at National Foundation for Cancer Research Conference, Woodshole, MA.
Coehn, A. 1898aZ. Phys. Chem. 25, 651.
Coehn, A. 1898b.Z. Elektorchem. 4, 501.
Coman, D. R. 1944.Cancer Res. 4, 625.
Coman, D. R. 1953.Cancer Res. 13, 397.
Cope, F. W. 1963.Bull. Math. Biophys. 25, 165 (see also Davson, 1959, for review).
Cope, F. W. 1980. InBioelectrochemistry (H. Keyzer and F. Gutmann, eds.). Plenum Press, New York.
Croce, C. M.; Koprowski, H. 1978 (Feb.).Sci. Am. 238, 117.
Davson, H. 1959. ATextbook of General Physiology, 2nd ed. J. and A. Churchill Ltd., London.
Del Duca, M. G., Fuscoe, J. M. 1965 (March).Internat. Sci. Tech. 5(3), 56.
Digby, P. S. B. 1965.Proc. Roy. Soc. 161B, 504.
Digby, P. S. B. 1972.Symp. Soc. Expt. Biol. 26, 445.
Donnan, F. G. 1911.Z. Elektro Chem. 17, S72.
Donnan, F. G. 1924.Chem. Rev. 1, 73.
Eley, D. D. 1962. InHorizons In Biochemistry (M. Kasha and B. Pullman, eds.). Academic Press, New York, pp. 341–380.
Falk, G.; Gerard, R. W. 1954.J. Cell. Comp. Physiol. 43, 393.
Fletcher, E. S.; Lilly, R. S.; Harkins, W. D. 1937.J. Gen. Physiol. 20, 671.
Fuller, R. C., Ed. 1959.The Photochemical Apparatus. Brookhaven National Laboratory, Upton, New York.
Gascoyne, P. R. C.; Pethig, R.; Szent-Györgyi, A. 1981.Proc. Nat. Acad. Sci. U. S. A. 78, 261.
Gergely, J. 1961. InElectrical Conductivity In Organic Solids (H. Kallmann and S. Silver, eds.). Wiley, New York, pp. 369–383.
Gingell, D.; Fornes, J. A. 1975.Nature 256, 211.
Grundfest, H.; Kao, C. Y.; Altamarino, M. 1954.J. Gen. Physiol. 38 245.
Gutmann, F.; Lyons, L. E. 1982.Organic Semiconductors, 2nd ed. (revised by F. Gutmann and H. Keyzer), Krieger, Melbourne.
Harris, E. J. 1960.Transport and Accumulation In Biological Systems, 2nd ed. Butterworths, London.
Hodgkin, A. 1951. Biol, Rev. Cambridge Philos, Soc. 26, 339.
Hodgkin, A.; Huxley, A. L. 1952. J. Physiol.117, 500.
John, T. L. 1971. Proceedings of Workshop in Bioelectrochemistry (ed. A. P. Pilla), National Science Foundation, Washington, D. C., pp. 225–267.
Januseviciene, T.; Kaikaris, V. 1965. Chem. Chem. Technol.6, 157.
Kallmann, H.; Silver, M. D. Eds. 1961.Electrical Conductivity In Organic Solids. Wiley, New York.
Kell, D. B. 1979. Biochim. Biophys. Acta549, 55.
Läuger, P.; Lesslauer, W.; Richter, J. 1967. Biochim. Biophys. Acta135, 20.
Ling, G. N. 1982.Physiol. Chem. Phys. 14, 47
Mandel, L. J. 1969. Electrodic Process in Biological Cells, Ph. D. Dissertation; University of Pennsylvania, Philadelphia.
Mandel, L. J. 1972. InModern Aspects of Electrochemistry, Vol. 8. (J. O'M. Bockris and B. E. Conway eds.), Plenum Press, New York.
Miller, E. C., Miller, J. A. 1974.Molecular Biology Of Cancer (H. Borsch, ed.). Academic Press, New York.
Mitchell, P. 1966. Biol. Rev. Cambridge Philos. Soc.41, 445.
Pethig, R. 1981 (Oct.). Paper at National Foundation for Cancer Research Conference, Woodshole, MA.
Pethig, R.; Szent-Györgyi, A. 1980. InBioelectrochemistry (H. Keyzer and F. Gutmann, eds.), Plenum Press, New York, p. 227.
Pilla, A. A. 1980. InBioelectrochemistry (H. Keyzer and F. Gutmann, eds.). Plenum Press, New York, p. 353.
Pohl, H. A.; Sauer, J. R. 1978. J. Biol. Phys.6, 118.
Pohl, H. A. 1979. J. Biol. Phys,7, 1.
Pohl, H. A. 1980. InBioelectrochemistry (H. Keyzer and F. Gutmann, eds.). Plenum Press, New York, p. 273.
Pohl, H. A. 1981a. Collective Phenomena3, 221.
Pohl, H. A. 1981b. J. Bioenerg. Biomembr.13, 149.
Pope, F.; Kallmann, H. 1961. InElectrical Conductivity In Organic Solids. Wiley, New York, pp. 83–104.
Rosenberg, B. 1962. J. Chem. Phys.36, 816.
Rosenberg, B.; Pant, H. C. 1970. Chem. Phys. Lipids.4, 203.
Rosenberg, B.; Pant, H. C. 1971. Chem. Phys. Lipids,6, 39.
Sebba, F. 1972. J. Colloid Interface Sci.40, 479.
Shaw, F. H.; Simons, S. E. 1955. Aust. J. Exp. Biol. Med. Sci.33, 153.
Shaw, F. H.; Simon, S. E.; Johnstone, B. M. 1956. J. Gen. Physiol.40, 1.
Spiro, T. G.; Stigliani, W. M. 1980.Environmental Issues In Chemical Perspective. State Univ. of New York Press, Albany, New York.
Szent-Gvörgvi, 1941. Nature148, 157.
Szent-Györgyi, A. 1969.Introduction to Submolecular Biology, Academic Press, New York.
Szent-Györgyi, A. 1972.The Living State, Academic Press, New York.
Szent-Györgyi, A. 1976.Electronic Biology And Cancer, Marcel Dekker, New York.
Szent-Györgyi, A. 1978.The Living State and Cancer. Marcel Dekker, New York.
Tien, H. T. 1974.Bilayer Lipid Membranes. Marcel Dekker, New York.
Tien, H. T.; Karvaly, B.; Shieh, P. K. 1977. J. Colloid Interface Sci.62, 185.
Tobias, J. M. 1950. J. Cell Comp. Physiol.26, 1.
Wagner, C.; Traud, W. 1938. Z. Electrochem.44, 391.
Zierler, K. (Chairman of Symposium). 1980. Fed. Proc.39, 492.
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Bockris, J.O.M., Habib, M.A. Are there electrochemical aspects of cancer?. J Biol Phys 10, 227–237 (1982). https://doi.org/10.1007/BF01991943
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DOI: https://doi.org/10.1007/BF01991943