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Synthesis of186Re-DMSA and its biodistributions in mice

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Abstract

Optimum conditions were determined for high-yield synthesis of186Re- and188Re-meso-2, 3-dimercaptosuccinic acid complexes applicable to animal injection. The yield was more than 95% under the conditions used. The bone accumulation of the complexes was remarkable in the biodistributions in mice.

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Authors and Affiliations

  1. Radioisotope Center, The University of Tokyo, Yayoi, Bunkyo-ku, 113, Tokyo, Japan

    N. Nogawa, Y. Makide & N. Morikawa

  2. Laboratory of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chiba University, Yayoi, Inage-ku, 263, Chiba-shi, Japan

    S. Momose, K. Miyazawa & K. Oohashi

  3. Japan Atomic Energy Research Institute, 319-11, Tokai-mura, Ibaraki-ken, Japan

    K. Hashimoto

Authors
  1. N. Nogawa
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  2. S. Momose
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  3. K. Miyazawa
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  4. Y. Makide
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  5. K. Oohashi
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  6. K. Hashimoto
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  7. N. Morikawa
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Nogawa, N., Momose, S., Miyazawa, K. et al. Synthesis of186Re-DMSA and its biodistributions in mice. J Radioanal Nucl Chem 239, 385–389 (1999). https://doi.org/10.1007/BF02349517

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  • DOI: https://doi.org/10.1007/BF02349517

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