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ior egf/r3: A murine monoclonal antibody for diagnostic of epithelial tumors

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Abstract

Monoclonal antibody ior egf/r3 is a IgG2a, recognizes the epidermal growth factor receptor. The aim of the present work was to evaluate the diagnostic efficacy of the99mTc-labeled ior egf/r3 for the detection of epithelial tumors, its metastasis and its recurrences. The sensitivity by organs was: brain 100%, diegestive tract 90%, head and neck 89%, lung 84% and breast 79%. The overall sensitivity, specificity, accuracy, positive predictive value and negative predictive value of the immunoscintigraphic imaging were 84.1%, 100%, 86.5%, 100% and 52.4%, respectively. Immunoscintigraphy with99mTc-ior egf/r3 is useful for the diagnosis and follow-up of epithelial tumors.

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Authors and Affiliations

  1. Center of Molecular Immunology, P.O.Box 16040, 11600, Havana, Cuba

    M. Ramos Suzarte, N. Iznaga, A. Morales, O. Torres & T. Rodríguez

  2. Center for Medical-Surgical Researches (CIMEQ), Calle 216 y 13, 11600, Havana, Cuba

    N. Rodríguez & N. Gonzalez

  3. National Institute of Oncology and Radiobiology, 29 y E, Vedado, Havana, Cuba

    J. P. Oliva

  4. Center of Clinical Researches, Calle 45 y 34, No. 4501, Rpto Kohly, Havana, Cuba

    A. Perera

Authors
  1. M. Ramos Suzarte
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  2. N. Rodríguez
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  3. J. P. Oliva
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  4. N. Iznaga
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  5. A. Perera
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  6. A. Morales
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  7. N. Gonzalez
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  8. O. Torres
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  9. T. Rodríguez
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Suzarte, M.R., Rodríguez, N., Oliva, J.P. et al. ior egf/r3: A murine monoclonal antibody for diagnostic of epithelial tumors. J Radioanal Nucl Chem 240, 499–503 (1999). https://doi.org/10.1007/BF02349402

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  • DOI: https://doi.org/10.1007/BF02349402

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