Abstract
5′-Deoxy-5′-[18F]fluoro-adenosine was synthesised by nucleophilic radiofluorination reactions of 5′-deoxy-5′-haloadenosines. The homogeneous isotope exchange in 5′-deoxy-5′-fluoro-adenosine was also investigated. The conversion of these reactions was found to be rather low and depends on the strength of the halogen-carbon bond: 0.248% for chloride-, 0.488% for bromide- and 1.070% for iodide-derivative; there was no reaction observed in the case of fluoro-compound.
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Lehel, S., Horváth, G., Boros, I. et al. Synthesis of 5′-deoxy-5′-[18F]fluoro-adenosine by Radiofluorination of 5′-deoxy-5′-haloadenosine Derivatives. Journal of Radioanalytical and Nuclear Chemistry 245, 399–401 (2000). https://doi.org/10.1023/A:1006791211919
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DOI: https://doi.org/10.1023/A:1006791211919