Abstract
A decaglutamic acid primer is extended very slowly byα-thioglutamic acid. The addition of bicarbonate to thereaction mixture greatly accelerates the reaction. We believethe N-carboxyanhydride of glutamic acid is an intermediate inthe accelerated reaction. When K3Fe(CN)6 andbicarbonate are both present in the reaction mixture,oligoglutamic acids up to at least the 15-mer are formedrapidly. The acylating agent is the oxidation product ofthioglutamic acid, a diacyldisulfide.
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Maurel, MC., Orgel, L.E. Oligomerization of α-Thioglutamic Acid. Orig Life Evol Biosph 30, 423–430 (2000). https://doi.org/10.1023/A:1006728514362
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DOI: https://doi.org/10.1023/A:1006728514362