Abstract
This short review tries to compile some results, which show the importance and the potential of plant cell and tissue cultures for a biotechnological production of natural products. On the other hand, it can not be denied, that a real breakthrough of this technique has not yet been achieved. The problems involved and possible ways to overcome these will be discussed.
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References
Akiu S, Suzuki Y, Fujinuma Y, Asahara T & Fukuda M (1988) Inhibitory effect of arbutin on melanogenesis: Biochemical study in cultured B16 melanoma cells and effect on the UV-induced pigmentation in human skin. Proc. Japan. Soc. Invest. Dermatol. 12, 138–139
Alfermann AW, Bergmann W, Figur C, helmbold U, Schwantag D, Schuller I & Reinhard E (1983) Biotransformation of β-methyldigitoxin to β-methyldigoxin by cell cultures ofDigitalis lanata. In: Mantell SH & Smith H (Eds) Plant Biotechnology (pp 67–74). Cambridge University Press, Cambridge, UK
Allison AJ, Butcher DN, Connolly JD & Overton KH (1968) Paniculides A, B, and C, bisabonolenoid lactones from tissue cultures ofAndrographis paniculata. Chem. Comm. 1493
Ball E (1967) Production of a group of anthocyanins in a callus culture under the influence of an auxin. Plant Physiol. 42 Suppl. S24
Berlin J, Wray V, Mollenschott C & Sasse F (1986) Formation of β-peltatin-A-methylether and coniferin by root cultures ofLinum flavum. J. Nat. Prod. 49:435–439
Broomhead AJ & Dewick PM (1990) Aryltetralin lignans fromLinum flavum andLinum capitatum. Phytochem 29:3839–3844
DeCapite L (1955) Azione degli zuccheri e delle basse temperature sulla formatione degli antociani in radici diDaucus carota coltivato in vitro. Ric. Sci. 35: 2091–2097
Eilert UFK, Kurz WGW & Constabel F (1985) Stimulation of sanguinarine accumulation inPapaver somniferum cell cultures by fungal elicitors. J Plant Physiol. 119:65–76
Farnsworth NR (1985) The role of medicinal plants in plants in drug development. In: Kroogsgard-Larsen P, Brogger Christensen S. & Koford H (Eds) Natural Products and Drug Development (pp 17–30) Munksgaard Copenhagen, Denmark
Fujita Y, Tabata M, Nishi A & Yamada Y (1982) New medium and production of secondary compounds with the two-staged culture method. In: Fujiwara A (Ed) Plant Tissue Culture 1982 (pp 399–400), Maruzen, Tokyo
Gautheret RJ (1939) Sur la possibilité de réaliser la culture indéfinle des tissus de tubercules de carotte. C. R. Acad. Sci., Paris, 208:118–120
Gautheret RJ (1941) Action du saccharose sur la croissance des tissus de carotte. C. R. Soc. Biol. 135:875–878
Gupta R (1991) Agrotechnology of Medicinal Plants In: Wijseker ROB (Ed) The Medicinal Plant Industry (pp 43–57). CRC Press, Boca Raton, USA
Haberlandt G (1902) Culturversuche mit isolierten Pflanzenzellen. Sitzungsberichte Math. Naturw. Kl. Kais. Akad. Wiss. Wien 111:69–92
Hampp N & Zenk MM (1988) Homogeneous strictosidine synthase from cell suspension cultures ofRauwolfia serpentina. Phytochem. 27:3811–3815
Hartmann T (1985) Principles of plant secondary metabolism. Plant Syst. Evol. 150:13–34
Hashimoto T & Yamada Y (1992) Biosynthesis of scopolamine and its application for genetic engineering of medicinal plants. In: Oono R, Hirabayashi T, Kiruchi S, Handa H & Kahwara S (Eds) Plant Tissue Culture and Gene Manipulation for Breeding and Formation of Phytochemicals (pp 255–259) National Institute of Agrobiological Resources, Tsukuba, Japan
Heide L & Tabata M (1987a) Enzyme Activities in Cell-Free Extracts of Shikonin-ProducingLithospermum erythrorhizon Cell Suspension Cultures. Phytochem. 26:1645–1650
Heide L & Tabata M (1987b) Geranylpyrophosphate:p-Hydroxybenzoate Geranyltransferase Activity in Extracts ofLithospermum erythrorhizon Cell Cultures. Phytochem. 26:1651–1655
Herbers K, Wilke I & Sonnewald U (1995) A thermostable xylanase fromClostridium thermocellum expressed at high levels in the apoplast of transgenic tobacco has no detrimental effects and is easily purified. Bio/Technology 13:63–66
Inoue H, Ueda S, Inoue K & Matsumura H (1979) Biosynthesis of shikonin in callus cultures ofLithospermum erythrorhizon. Phytochemistry 18:1301–1308
Kesselring (1985) Pflanzenzellkulturen (PZK) zur Auffindung neuer, therapeutisch relevanter Naturstoffe und deren Gewinnung durch Fermentationsprozesse. In: Bundesminister für Forschung und Technology (Ed) Pflanzliche Zellkulturen (pp 111–129). Projektträger Biotechnologie, KFA Jülich, Germany
Kurz WGW, Tyler RT & Roewer IA (1990) Elicitation — A method to induce metabolite production by plant cells. In: Durand G, Bobichon L & Florent J (Eds) Proc. 8th Int. Biotechnol. Symp. vol. 1 (pp 193–204), Soc. Franc. Microbiol., Paris, France
Kutchan TM (1989) Expression of enzymatically active cloned strictosidine synthase from the higher plantRauwolfia serpentina inEscherichia coli. FEBS Lett. 257:127–130
Kutchan T, Dittrich H, Bracher D & Zenk MH (1991) Enzymology and molecular biology of alkaloid biosynthesis. Tetrahedron 47:5945–5954
Lutterbach R & Stöckigt J (1992) High-yield formation of arbutin from hydroquinone by cell-susspension cultures ofRauwolfia serpentina. Helv. Chim. Acta 75:2009–2011
Lutterbach R, Ruyter CM & Stöckigt J (1994) Isolation and characterization of an UDPG-dependent glucosyltransferase activity fromRauwolfia serpentina Benth. cell suspension cultures. Can. J. Chem. 72:51–55
Mizukami H, Terato T, Miura H & Ohashi H (1983) Glucosylation of salicyl alcohol in cultured plant cells. Phytochem. 22:679–680
Mizukami H, Terato T & Ohashi H (1985) Partial purification and characterization of UDP-glucose:salicyl alcohol glucosyltransferase fromGardenia jasminoides cell cultures. Planta Me. 46:104–107
Mizukami H, Terato T, Amano A & Ohashi H (1986) Glucosylation of salicyl alcohol byGardenia jasminoides cell cultures. Plant Cell Physiol. 27:645–650
Mizukami H, Terato T & Ohashi H (1987) Effect of substituent groups on the glucosyl formation of xenobiotic phenols by cultured cells ofGardenia jasminoides. Plant Sci. 48:11–15
Nobécourt P (1937) Culture en série de tissus végétaux sur milieu artificiel. C.R. Séances Soc. Biol. 205:521–523
Pabsch K, Petersen M, Rao NN, Alfermann AW & Wandrey C (1991) Chemo-enzymatic synthesis of rosmarinic acid. Rec. Trav. Chim. Pays-Bas 110:199–205
Petersen M (1995) Plant cell cultures as a source of enzymes involved in natural product biosynthesis. Proc. 7th Europ. Congr. Biotechnol., Nice February 19–23, in press
Petersen M & Seitz HU (1985) Cytochrome P-450 dependent digitoxin 12β-hydroxylase from cell cultures ofDigitalis lanata. FEBS Lett. 188:11–14
Petersen M & Seitz HU (1988) Reconstitution of cytochrome P-450 dependent digitoxin 12β-hydroxylase from cell cultures ofDigitalis lanata Ehrh. Biochem. J. 252:537–543
Petersen M, Seitz HU & Reinhard E (1988) Characterisation and localisation ofdigitoxin 12β-hydroxylase from cell cultures ofDigitalis lanata Ehrh. Z. Naturforsch. 43c:199–206
Petersen M, Alfermann AW, Reinhard E & Seitz HU (1987) Immobilization of a 12β-hydroxylase from cell suspension cultures ofDigitalis lanata Ehrh. Plant Cell Rep. 6:200–203
Petersen M, Dombrowski K, Gertlowski C, Häusler E, Karwatzki B, Meinhard J & Alfermann AW (1992) The use of plant cell cultures to study natural product biosynthesis. In: Oono R, Hirabayashi T, Kiruchi S, Handa H & Kahwara S (Eds) Plant Tissue Culture and Gene Manipulation for Breeding and Formation of Phytochemicals (pp 297–310) National Institute of Agrobiological Resources, Tsukuba, Japan
Pfitzner U & Zenk MH (1982) Immobilization of strictosidine synthase from Catharanthus cell cultures and preparative synthesis of strictosidine. Planta Med. 46:10–14
Pilgrim H (1970) Untersuchungen zur Glycosidbildung in pflanzlichen Gewebekulturen. Pharmazie 25:568
Reinert J, Clauss H & von Ardenne R (1964) Anthocyanbildung in Gewebekulturen vonHaplopappus gracilis in Licht verschiedener Qualität. Naturwiss. 51:87
Romeike A (1960) Die Rolle von Sproβ und Wurzel bei der Umwandlung des Hyoscyamins in verschiedenenDatura Arten. Planta Medica 8:491–496
Routien JB & Nickel LG (1952) Cultivation of Plant Tissue. US Patent 2,747,334
Ruyter CM & Stöckigt J (1989) Novel natural products from plant cell and tissue cultures—an update. GIT Fachz. Lab. 4:283–293
Scott AI (1994) Genetically engineered synthesis of natural products. J. Nat. Prod. 57:557–573
Stöckigt J (1993) Biotransformations with plant cells. Agro-Food-Industry Hi-Tech:25–28
Suzuki T, Yoshioka T, Tabata M & Fujita Y (1987) Potential ofDatura innoxia cell suspension cultures for glycosylating hydroquinone. Plant Cell Rep. 6:275–278
Tabata M, Ikeda F, Hiraoka N & Konoshima M (1976) Glucosylation of phenolic compounds byDatura innoxia suspension cultures. Phytochem. 15:1225–1229
Tabata M, Umetani Y, Ooya M & Tanaka S (1988) Glucosylation of phenolic compounds by plant cell cultures. Phytochem. 27:809–813
Tanaka S, Hayakawa K, Umetani Y & Tabata M (1990) Glucosylation of isomeric hydroxybenzoic acids by cell suspension cultures ofMallotus japonicus. Phytochem. 29:1555–1558
Treimer JF & Zenk MH (1979) Purification and properties of strictosidine synthase, the key enzyme in indole alkaloid formation. Eur. J. Biochem. 101:225–233
Ushiyama K (1991) Large scale cultivation of ginseng. In: Komamine A, Misawa A & DiCosmo F (eds) Plant Cell Cultures in Japan (pp 92–98) CMC, Tokyo, Japan
Yokoyama M & Yanagi M (1991) High level production of arbutin by biotransformation. In: Komamine A & Misawa M (Eds) Plant Cell Culture in Japan (pp 79–91). CMC, Tokyo, Japan
Wahl J (1985) Adaption konventioneller Fermenter zur Züchtung von Pflanzenzellen zum Zwecke der Gewinnung von Naturstoffen. In: Bundesminister für Forschung und Technology (Ed.) Pflanzliche Zellkulturen (pp 35–43). Projektträger Biotechnologie, KFA Jülich, Germany
Westphal K (1990) Large scale production of new biologically active compounds in plant cell cultures. In: Nijkamp HJJ, van der Plas LHW & van Aartrijk J (Eds) Progress in Plant Cellular and Molecular Biology (pp 601–608). Kluwer, Dordrecht, The Netherlands
White PR (1939) Potentially unlimited growth of excised plant callus in an artificial medium. Am. J. Bot. 26:59–64
Zenk MH, El-Shagi H, Arens H, Stöckigt J, Weiler EW & Deus B (1977) Formation of indole alkaloids serpentine and ajmalicine in cell suspension cultures ofCatharanthus roseus. In: Barz W, Reinhard E & Zenk MH (Eds) Plant Tissue Culture and its Bio-Technological Application (pp 27–43). Springer Verlag, Berlin, Germany
Zenk MH (1991) Chasing the enzymes of secondary metabolism: Plant Cell Cultures as a pot of gold. Phytochem. 30: 3861–3863
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Dedicated to the memory of Prof. Dr. G. Haberlandt on the occasion of the 50th anniversary of his death
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Alfermann, A.W., Petersen, M. Natural product formation by plant cell biotechnology. Plant Cell Tiss Organ Cult 43, 199–205 (1995). https://doi.org/10.1007/BF00052176
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DOI: https://doi.org/10.1007/BF00052176