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Disposition kinetics and urinary excretion of gentamicin in buffalo bulls (Bubalus bubalis)

  • Pharmacology
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Abstract

The disposition kinetics and urinary excretion of gentamicin sulphate were studied in young buffalo bulls following a single intramuscular administration of the drug at 5 mg kg-1 body weight. The time course of the serum gentamicin concentration was adequately described by the one-compartment open model. The values of the absorption and elimination halflives were 12.2±2.2 and 167.0±29.7 min respectively. The apparent volume of distribution was 0.29±0.01 L kg-1. During the first 12 h, 63% of the total administered dose was excreted in urine. On the basis of the kinetic data, a satisfactory intramuscular dosage regimen for gentamicin sulphate would be at least 6 mg kg-1 body weight repeated at 8 h intervals.

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Author notes

  1. S. K. Garg

    Present address: College of Veterinary Science, Himachal Pradesh Krishi Vishna Vidyalaya, 176062, Palampur, India

Authors and Affiliations

  1. Department of Veterinary Pharmacology, Haryana Agricultural University, 125004, Hisar, India

    S. K. Garg & B. D. Garg

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  1. S. K. Garg
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  2. B. D. Garg
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Garg, S.K., Garg, B.D. Disposition kinetics and urinary excretion of gentamicin in buffalo bulls (Bubalus bubalis). Vet Res Commun 13, 331–337 (1989). https://doi.org/10.1007/BF00420840

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  • DOI: https://doi.org/10.1007/BF00420840

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