Abstract
The disposition kinetics and appropriate dosage regimen for kanamycin were investigated in buffalo calves following a single intravenous dose of 10 mg/kg body weight. The distribution and elimination half-lives were 0.12±0.01 h and 1.94±0.11 h, respectively. The apparent volume of distribution and total body clearance were 0.2±0.01 L/kg and 92.9±3.69 ml/kg/h, respectively. About 74% of the administered dose was excreted in urine in 24 h. A suitable dosage regimen for the intravenous administration of kanamycin was also calculated.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- SEM:
-
standard error of the mean
References
Arret, B., Johnson, D.P. and Krishbaum, A., 1971. Outline of details of microbiological assay of antibiotics.Journal of Pharmaceutical Sciences,60, 1689–1694
Baggot, J.D., 1977.Principles of Drug Disposition in Domestic Animals: The Basis of Veterinary Clinical Pharmacology, (W.B. Saunders, Philadelphia), 144–189
Baggot, J.D., 1978. Pharmacokinetics of kanamycin in dogs.Journal of Veterinary Pharmacology and Therapeutics,1, 163–170
Baggot, J.D., Love, D.M., Bose, R.S. and Raus, J., 1981. The pharmacokinetics of some aminoglycoside antibiotics in the horse.Journal of Veterinary Pharmacology and Therapeutics,4, 277–284
Brown, M.P., Stover, S.M., Kelly, R.H. and Farver, T.B., 1981. Kanamycin sulfate in horses: serum, synovial fluid, peritoneal fluid and urine concentration after single-dose intramuscular administration.American Journal of Veterinary Research,42, 1823–1825
Cunningham, G.R., 1970. Ophthalmic kanamycin in small animals.Veterinary Medicine Small Animal Clinic,65, 983–986
Gibaldi, M. and Perrier, D., 1975.Pharmacokinetics, (Marcel Dekker, New York)
Klasterky, J., 1984. Antibiotic synergy and antagonism. In:Antimicrobial Therapy, Rustuccia, A.M., and Curha, B.A. (eds.), (Raven Press, New York), 37–53
Leroy, A., Humbert, G., Oksenhendler, G. and Fillastre, J.P., 1976. Comparative pharmacokinetics of rividomycin, amikacin and siromicin in normal subjects and in uraemic patients.Journal of Antimicrobial Agents and Chemotherapy,2, 373–381
Ling, G.V., Conzelman, G.M. Jr., Franti, C.E. and Ruby, A.L., 1981. Urine concentrations of gentamycin, tobramycin, amikacin and kanamycin after subcutaneous administration to healthy adult dogs.American Journal of Veterinary Research,42, 1792–1794
Soulages, C.A., 1976. Effect of kanamycin used therapeutically in swine.Veterinaria (Gaceta),38, 334–338
Verma, K.J., Paul, B.S. and Gupta, R.C., 1980. Pharmacokinetic disposition and plasma protein binding (in vitro) of chloramphenicol inBubalus bubalis.Journal of Veterinary Pharmacology and Therapeutics,3, 151–155
Ziv, G., 1977. Comparative clinical pharmacology of amikacin and kanamycin in dairy calves.American Journal of Veterinary Research,38, 337–340
Ziv, G. and Sulman, F.G., 1974. Distribution of aminoglycoside antibiotics in blood and milk.Research in Veterinary Science,17, 68–74
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rampal, S., Srivastava, A.K. & Chaudhary, R.K. Disposition kinetics, urinary excretion and dosage regimen of kanamycin in buffalo calves following single intravenous administration. Vet Res Commun 17, 219–225 (1993). https://doi.org/10.1007/BF01839170
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01839170