Abstract
The pharmacokinetics, penetration into erythrocytes and plasma protein binding of cefotaxime were investigated in cross-bred calves. Following a single intramuscular dose of cefotaxime (10 mg/kg), the absorption half-life and elimination half-life were 0.13±0.03 h and 2.97±0.72 h, respectively. The apparent volume of distribution and total body clearance were 3.28±0.72 L/kg and 0.78±0.08 L/kg per h, respectively. The extent of penetration into erythrocytes was 24–40% of the total blood concentration. Cefotaxime was bound to plasma proteins of calves to the extent of 25.5–33.6%. A satisfactory intramuscular dosage regimen for cefotaxime in calves would be 11 mg/kg followed by 10 mg/kg at 7 h intervals.
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Abbreviations
- ATCC:
-
American type cell culture
- MIC:
-
minimum inhibitory concentration
- PCV:
-
packed cell volume
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Sharma, S.K., Srivastava, A.K. Pharmacokinetics and dosage regimen of cefotaxime in cross-bred calves following single intramuscular administration. Vet Res Commun 18, 313–318 (1994). https://doi.org/10.1007/BF01839199
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DOI: https://doi.org/10.1007/BF01839199