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Caffeine clearance in the horse

  • Pharmacology
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Abstract

The pharmacokinetic properties of intravenously administered caffeine were studied in 10 horses using a commercially available automated enzyme immunoassay. The harmonic mean for the distribution half-life was 5.2 min (range 1.4–18.7). The harmonic mean for the elimination half-life was 10.18 h (range 6.82–20.92). The harmonic mean of the volume of distribution was 0.32 L/kg (range 0.22–0.53). There was no correlation between the dose of caffeine/kg body weight and the elimination half-life (Spearman's coefficient of rank correlation =0.19).

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Abbreviations

AUC:

area under the serum concentration-time curve

AUMC:

area under the moment curve

BSP:

sulphobromophthalein

ICG:

indocyanine green

SD:

standard deviation

t 1/2β :

elimination half-life

V c :

apparent volume of the central compartment

V d(ss) :

apparent volume of distribution at steady state

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Authors and Affiliations

  1. Department of Large Animal Surgery and Medicine, College of Veterinary Medicine, Auburn University, 36849-5522, AL, USA

    J. Schumacher, F. J. DeGraves, S. H. Duran & D. C. Ruffin

  2. Department of Pathobiology, College of Veterinary Medicine, Auburn University, 36849-5522, AL, USA

    J. S. Spano

  3. Department of Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, 36849-5522, AL, USA

    R. C. Wilson

Authors
  1. J. Schumacher
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  2. J. S. Spano
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  3. R. C. Wilson
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  4. F. J. DeGraves
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  5. S. H. Duran
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  6. D. C. Ruffin
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Schumacher, J., Spano, J.S., Wilson, R.C. et al. Caffeine clearance in the horse. Vet Res Commun 18, 367–372 (1994). https://doi.org/10.1007/BF01839287

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  • DOI: https://doi.org/10.1007/BF01839287

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