Abstract
Knox, M.R. and Steel, J.W., 1997. Effects of diet and species on the pharmacokinetics of fenbendazole in cattle. Veterinary Research Communications, 21 (1), 37-43.
The plasma concentration profiles of fenbendazole (FBZ), FBZ-sulphoxide (OFZ) and FBZ-sulphone were measured following intraruminal administration of FBZ at 7.5 mg/kg bodyweight in Bos taurus and B. indicus cattle offered three different diets: 100% wheaten chaff, 100% lucerne, and a 50:50 mix of these two diets. No differences between the species were apparent except for a longer time to peak plasma concentration for OFZ in the B. taurus steers fed 100% wheaten chaff. Cattle fed wheaten chaff alone gave greater areas under the concentration-time curve and longer persistence for all metabolites than when the same cattle were fed the other diets. It is concluded that the reduced rate of passage of digesta on lower-quality fibrous diets allows greater time for absorption of FBZ and its metabolites from the gut, thereby increasing systemic availability.
Similar content being viewed by others
REFERENCES
Ali, D.N. and Chick, B.F., 1992. The effect of feed type on the pharmacokinetic disposition of oxfendazole in sheep. Research in Veterinary Science, 52, 382–383
Ali, D.N. and Hennessy, D.R., 1993. The effect of feed intake on the rate of flow of digesta and the disposition and activity of oxfendazole in sheep. International Journal for Parasitology, 23, 477–484
Benchaoui, H.A., Futter, I.J., Holton, L.L., Gettinby, G. and McKellar, Q.A., 1995. Bioavailability of different benzimidazole volume-dose formulations in sheep. The Veterinary Record, 137, 171–172
Brown, R.D. and Manno, J.E., 1978. ESTRIP, a BASIC computer program for obtaining initial polyexponential parameter estimates. Journal of Pharmaceutical Sciences, 67 1687–1691
Hennessy, D.R., Lacey, E., Prichard, R.K. and Steel, J.W., 1985. Potentiation of the anthelmintic activity of oxfendazole with parbendazole. Journal of Veterinary Pharmacology and Therapeutics, 12, 270–275
Hennessy, D.R., Sangster, N.C., Steel, J.W. and Collins, G.H., 1993a. Comparative pharmacokinetic behaviour of albendazole in sheep and goats. International Journal for Parasitology, 23, 321–325
Hennessy, D.R., Sangster, N.C., Steel, J.W. and Collins, G.H., 1993b. Comparative kinetic disposition of oxfendazole in sheep and goats before and during infection with Haemonchus contortus and Trichostrongylus colubriformis. Journal of Veterinary Pharmacology and Therapeutics, 16, 245–253
Hennessy, D.R., Ali, D.N. and Sillince, J., 1995. The effect of short-term reduction in feed on the pharmacokinetic and efficacy of albendazole in sheep. Australian Veterinary Journal, 72, 29–30
Hunter, R.A. and Siebert, B.D., 1985. Utilization of low-quality roughage by Bos taurus and Bos indicus cattle. 2. The effect of rumen degradable nitrogen and sulphur on voluntary food intake and rumen characteristics. British Journal of Nutrition, 53, 649–656
Knox, M.R., Kennedy, P.M., Hennessy, D.R., Steel, J.W. and Le Jambre, L.F., 1994. Comparative pharmacokinetics of fenbendazole in buffalo and cattle. Veterinary Research Communications, 18, 209–216
Knox, M.R., Steel, J.W., Ali, D.N. and Le Jambre, L.F., 1995. A comparison of plasma metabolite levels in goats and sheep during continuous low-level administration of fenbendazole. Veterinary Research Communications, 19, 159–165
Lanusse, C., Sanchez, S. and Alvarez, L., 1994. Influence of fasting and nutritional status on the kinetics of albendazole in cattle. In: P. Lees (ed.), Proceedings of the 6th International Congress of the European Association for Veterinary Pharmacology and Toxicology, Edinburgh, August 1994, (Blackwell Scientific, Oxford), 249–250
McKellar, Q.A., Coop, R.L. and Jackson, F., 1995. The pharmacokinetics of albendazole metabolites following administration of albendazole, albendazole sulfoxide and netobimin to one-month-and eight-month-old sheep. International Journal for Parasitology, 25, 1207–1212
Ngomuo, A.J., Marriner, S.E. and Bogan, J.A., 1984. The pharmacokinetics of fenbendazole and oxfendazole in cattle. Veterinary Research Communications, 8, 187–193
Prichard, R.K., Hennessy, D.R., Steel, J.W. and Lacey, E., 1985. Metabolite concentrations in plasma following treatment of cattle with five anthelmintics. Research in Veterinary Science, 39, 173–1787
Sangster, N.C., Rickard, J.M., Hennessy, D.R., Steel, J.W. and Collins, G.H., 1991. Disposition of oxfendazole in goats and efficacy compared with sheep. Research in Veterinary Science, 51, 258–263
Sanyal, P.K., Knox, M.R., Singh, D.K., Hennessy, D.R. and Steel, J.W., 1995. Influence of diet type on the kinetic disposition of fenbendazole in cattle and buffalo. International Journal for Parasitology, 25, 1201–1205
Short, C.R., Barker, S.A., Hsieh, L.C., Ou, S.-P., McDowell, T., Davis, L.E., Neff-Davis, C.A., Koritz, G., Bevill, R.F. and Munsiff, I.J., 1987. Disposition of fenbendazole in cattle. American Journal of Veterinary Research, 48, 958–961
Short, C.R., Flory, W., Hsieh, L.C. and Barker, S.A., 1988. The oxidative metabolism of fenbendazole: a comparative study. Journal of Veterinary Pharmacology and Therapeutics, 11, 50–55
Shumaker, R.C., 1986. PKCALC: A BASIC interactive computer program for statistical and pharmacokinetic analysis of data. Drug Metabolism Reviews, 17, 331–348
Taylor, S.M., Mallon, T.R., Blanchflower, W.J., Kennedy, D.G. and Green, W.P., 1992. Effects of diet on plasma concentrations of oral anthelmintics for sheep and cattle. Veterinary Record, 130, 264–268
Warner, A.C.I., 1981. Rate of passage of digesta through the gut of mammals and birds. Nutrition Abstracts and Reviews Series B, 51, 789–820
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Knox, M., Steel, J. Effects of Diet and Species on the Pharmacokinetics of Fenbendazole in Cattle. Vet Res Commun 21, 37–43 (1997). https://doi.org/10.1023/B:VERC.0000009699.60051.e1
Issue Date:
DOI: https://doi.org/10.1023/B:VERC.0000009699.60051.e1