Abstract
Exposure of Krushinsky-Molodkina rats (a strain genetically predisposed to audiogenic epilepsy) to multiple electrostimulation (a course consisting of 10 sessions) prolongs the latency of epileptic seizures, lowers blood levels of stress hormones, lessens the severity of seizures, and reduces by half the area occupied by subdural hemorrhages. It is concluded that the major role in the mechanism of these protective effects is played by adaptation to stress, accompanied by the accumulation in the brain of heat-shock proteins that stabilize cellular structures.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, No 2, pp. 127–129, February, 1994
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Meerson, F.Z., Pinelis, V.G., Koshelev, V.B. et al. Adaptation to multiple electrostimulation limits hemorrhages in the brain of rats with audiogenic epilepsy. Bull Exp Biol Med 117, 125–128 (1994). https://doi.org/10.1007/BF02444121
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DOI: https://doi.org/10.1007/BF02444121