Abstract
The relative capacity of substances of the pentarane group for binding with progesterone receptors of the plasma membranes of uterine cells of oophorectomized rats is studied. Introduction of an extra carbocycle D' in the progesterone molecule at the 16α and 17α sites and further modification of the molecule cause an increase of the relative binding capacity of these compounds. Analysis of the findings identifies substance III, showing the highest activity toward all the discussed parameters and a promising candidate for further preclinical studies.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol., 118, No 7, pp. 31–32, July, 1994
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Sergeev, P.V., Kamernitskii, A.V., Levina, I.S. et al. Relative binding capacity of pentarane substances with plasma membrane receptors of uterine cells of oophorectomized rats. Bull Exp Biol Med 118, 711–713 (1994). https://doi.org/10.1007/BF02444364
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DOI: https://doi.org/10.1007/BF02444364