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Impaired plasticity of hippocampal synaptic transmission in rats exposed to prenatal hypoxia is normalized by treatment with nootropic dipeptides

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Experiments on hippocampal slices from young rats exposed to hypobaric hypoxia duringin utero development revealed enhanced responsiveness (an increase in a CA1 field response amplitude) and reduced plasticity (a low incidence of field response long-term potentation following high-frequency stimulation) of CA1 pyramidal neurons. Postnatal treatment of animals with piracetam peptide analogs constructed on the basis of pyroglutamate and proline normalized both these physiological indices.

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Authors and Affiliations

  1. Brain Research Institute, Russian Academy of Medical Sciences, Moscow

    A. N. Chepkova & V. G. Skrebitskii

  2. Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow

    S. S. Trofimov, N. I. Smol'nikova, T. A. Gudasheva & R. U. Ostrovskaya

Authors
  1. A. N. Chepkova
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  2. S. S. Trofimov
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  3. N. I. Smol'nikova
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  4. T. A. Gudasheva
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  5. R. U. Ostrovskaya
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  6. V. G. Skrebitskii
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, No 12, pp. 592–595, December, 1995

Presented by G. N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences

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Chepkova, A.N., Trofimov, S.S., Smol'nikova, N.I. et al. Impaired plasticity of hippocampal synaptic transmission in rats exposed to prenatal hypoxia is normalized by treatment with nootropic dipeptides. Bull Exp Biol Med 120, 1208–1210 (1995). https://doi.org/10.1007/BF02445573

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  • DOI: https://doi.org/10.1007/BF02445573

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