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Pharmacokinetics of antipyrine in rats with different resistance to hypoxia in cold stress

  • General Pathology and Pathological Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

It is shown that the parameters of antipyrine pharmacokinetics during cold exposure depend on individual resistance to hypoxia. High-resistant rats are characterized by less intense metabolism and more rapid normalization of pharmacokinetic parameters than lowresistant rats characterized by shortened elimination half-time corresponding to a more rapid metabolism of xenobiotics under conditions of cold stress.

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Authors and Affiliations

  1. Laboratory of Clinical Problems of Ecology, Institute of Regional Pathology and Pathological Morphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Novosibirsk, USSR

    Yu. P. Gichev, E. O. Guseva, O. P. Grek & V. I. Sharapov

  2. Department of Pharmacology, Novosibirsk Medical Institute, Novosibirsk, USSR

    Yu. P. Gichev, E. O. Guseva, O. P. Grek & V. I. Sharapov

Authors
  1. Yu. P. Gichev
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  2. E. O. Guseva
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  3. O. P. Grek
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  4. V. I. Sharapov
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 11, pp. 513–515, November, 1998

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Gichev, Y.P., Guseva, E.O., Grek, O.P. et al. Pharmacokinetics of antipyrine in rats with different resistance to hypoxia in cold stress. Bull Exp Biol Med 126, 1098–1099 (1998). https://doi.org/10.1007/BF02447243

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  • DOI: https://doi.org/10.1007/BF02447243

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