Abstract
In patients with lung cancer and malignant tumors of the head and neck, erythrocyte hyperpolarization associated with the opening of Ca2+-activated potassium channels develops with lower rate and amplitude compared with that in healthy donors. Restoration of normal membrane potential is Ca2+-ATPase-dependent. The rate of restoration is significantly higher in patients with tumors. Two groups with different hyperpolarization response and their dynamics during chemotherapy were identified in patients with lung cancer. Ca2+-induced erythrocyte hyperpolarization and its dynamics during cytostatic therapy depend on tumor localization and histological type.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 1, pp. 77–80, January 1999
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Petrova, I.V., Sokolova, I.B., Stepovaya, E.A. et al. Ca2+-induced erythrocyte hyperpolarization in patients with tumors of different localization. Bull Exp Biol Med 127, 69–72 (1999). https://doi.org/10.1007/BF02432805
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DOI: https://doi.org/10.1007/BF02432805