Abstract
Both specific (lipid deposition in endotheliocytes, myocytes, and pericytes) and non-specific (intense formation of apical processes and vacuoles in endotheliocytes and vacuolization of myocytes) changes in cerebral vessels of different diameter were revealed in rabbits and rats after 4 months of experimental hyperlipidemia. These changes suggest reduced endothelium athrombogeneity and intensified transendothelial transport. Biochemical and morphological manifestations of hyperlipidemia in rabbits were more pronounced than in rats.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 2, pp. 234–240, February, 2000
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Gulevskaya, T.S., Lozhnikova, C.M., Sakharova, A.V. et al. Changes in cerebral vessels during experimental hyperlipidemia. Bull Exp Biol Med 129, 201–206 (2000). https://doi.org/10.1007/BF02434811
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DOI: https://doi.org/10.1007/BF02434811