The function of the physiological anticoagulation system in reticuloendothelial block

Summary

Trypane blue block of reticuloendothelium in rats provoked some reduction in the protective function of the physiological anticoagulation system. Mortality rate after intravenous administration of thromboplastin (in moderate doses), obtained from the brain tissue of rats, is considerably great in animals with reticuloendothelial block than that in the controls receiving the same thromboplastin doses. The protective reaction of the organism to the thromboplastin administered in the jugular vein is less pronounced during reticuloendothelial block, the rise of the blood fibrinolytic activity in resonse to the administered thromboplastin being less marked in the experimental animals than in the controls. As compared to controls thrombin time of blood subjected to preliminary incubation with protaminsulfate is reduced in the experimental animals, pointing to a lesser discharge or of heparin-like substances in their blood. The restoration of the normal blood coagulation time in the surviving experimental animals was relatively more rapid than in controls.