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Investigation of the ability of dicoumarin to prevent thrombosis caused by intravenous injection of massive doses of thromboplastin

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Dicoumarin was used to reduce the blood prothrombin to the therapeutic level (25–12%) and below 10% in male albino rats; thrombin formation was induced by thromboplastin administration against the background of the normally functioning anticoagulation system and of its depression (caused by keeping the animals on atherogenic diet and by chloropromazine or potassium chloride administration). As established, reliable protection from thrombosis could be attained only by reducing the prothrombin level below the 10% mark. The most prothrombin state developed after intravenous injection of potassium chloride.

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Literature Cited

  1. G. G. Bazaz'yan, N. P. Sytina, G. V. Andreenko, et al. Byull. éksper. biol.,10, 26 (1961).

    Google Scholar 

  2. T. M. Kalishevskaya and B. A. Kudryashov, Fiziol. zh. SSSR,10, 1234 (1962).

    Google Scholar 

  3. B. A. Kudryashov, P. D. Ulitina, and A. A. Pugachev, Byull. éksper. biol.,11, 6, 510 (1941).

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Authors and Affiliations

  1. Laboratory of the Biochemistry and Physiology of Blood Coagulation, Faculty of Soil Biology, Order of Lenin M. V. Lomonosov Moscow State University, Moscow, Russia

    B. A. Kudryashov, M. D. Ushakova, G. G. Bazaz'yan & N. P. Sytina

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  1. B. A. Kudryashov
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  2. M. D. Ushakova
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  3. G. G. Bazaz'yan
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  4. N. P. Sytina
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Kudryashov, B.A., Ushakova, M.D., Bazaz'yan, G.G. et al. Investigation of the ability of dicoumarin to prevent thrombosis caused by intravenous injection of massive doses of thromboplastin. Bull Exp Biol Med 57, 273–274 (1964). https://doi.org/10.1007/BF00781905

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  • DOI: https://doi.org/10.1007/BF00781905

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