Abstract
Experiments on sexually mature female rats showed that daily simultaneous administration of mestranol (0.04 mg/kg) and megestrol acetate (0.8 mg/kg) by gastric tube for 14 days had no appreciable contraceptive effect, whereas administration of the steroids in the same doses combined with antiadrenergic drugs α-methyldopa (100 mg/kg) or pyrroxan (10 mg/kg) effectively prevented pregnancy.
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Korkhov, V.V., Veshchilova, T.P. Contraceptive activity of combinations of steroid and antiadrenergic preparations. Bull Exp Biol Med 79, 427–429 (1975). https://doi.org/10.1007/BF00832717
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DOI: https://doi.org/10.1007/BF00832717