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Primary breast sarcoma: A review of 33 cases with immunohistochemistry and prognostic factors

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Abstract

The clinical and pathological features of 33 previously untreated patients with primary breast sarcoma were retrospectively analysed to evaluate the prognostic significance of histologic variables on survival. The series comprised 17 cystosarcomas phyllodes and 16 stromal sarcomas (excluding angiosarcomas).

All tumors were reviewed and classified in similar fashion to extramammary soft tissue sarcomas. In addition, immunohistochemical studies were performed on paraffin sections with a panel of several antibodies directed against cytoskeletal filaments and cellular enzymes; five cases were also examined by electron microscopy.

Most tumors were malignant fibrous histiocytoma (21 cases) and fibrosarcoma (6 cases) types. Surgery was the main therapy. Metastasis-free survival rate was significantly correlated only with histological grade, consisting of tumor differentiation, tumor necrosis, and mitotic activity. Courses and survivals of the cystosarcoma and stromal groups were identical, questioning the clinical value of this pathologic distinction. All local recurrence, metastasis, or death occurred within 30 months, though follow-up was much longer.

Immunohistochemistry was disappointing for identification of specific histologic sub-types.

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References

  1. Oberman HA: Sarcomas of the breast. Cancer 10: 1233–1243, 1965

    Google Scholar 

  2. Barnes L, Pietruszka M: Sarcomas of the breast: A clinicopathologic analysis of ten cases. Cancer 40: 1577–1585, 1977

    PubMed  Google Scholar 

  3. Callery CD, Rosen PP, Kinne DW: Sarcomas of the breast. A study of 32 patients with reappraisal of classification and therapy. Ann Surg 201: 527–532, 1985

    PubMed  Google Scholar 

  4. Spielmann M, Toussaint C, Malcoste G, Le Chevalier T, Mondesir JM, Contesso G, Sarrazin D, Genin J, Rouësse J: Les sarcomes mammaires mésenchymateux. A propos de 25 cas. Bull Cancer (Paris) 72: 202–209, 1985

    Google Scholar 

  5. Norris HJ, Taylor HB: Relationship of histologic features to behavior of cystosarcoma phyllodes. Analysis of ninetyfour cases. Cancer 20: 2090–2099, 1967

    PubMed  Google Scholar 

  6. Azzopardi JG: Problems in Breast Pathology. Saunders, London 1979

    Google Scholar 

  7. Ward RM, Evans HL: Cystosarcoma phyllodes. A clinicopathologic study of 26 cases. Cancer 58: 2282–2289, 1986

    PubMed  Google Scholar 

  8. Berg JW, De Crosse JJ, Fracchia AA, Farrow J: Stromal sarcomas of the breast. A unified approach to connective tissue sarcomas other than cystosarcomas phyllodes. Cancer 15: 418–424, 1962

    PubMed  Google Scholar 

  9. Lattes R: Sarcomas of the breast. Int J Radiat Oncol Biol Phys 4: 705–708, 1978

    PubMed  Google Scholar 

  10. André JM, Contesso G, Caillou B, Lacombe MJ, Spielmann M: Lymphomes malins et autres hématosarcomes à localisation mammaire initiale. Etude rétrospective de 20 cas. Bull Cancer (Paris) 70: 401–409, 1983

    Google Scholar 

  11. Enzinger FM, Weiss SW: Soft Tissue Tumors. Mosby, Saint Louis 1983.

    Google Scholar 

  12. Trojani M, Contesso G, Coindre JM, Rouësse J, Bui ME, de Mascarel A, Groussot JF, David M, Bonichon F, Lagarde C: Soft tissue sarcomas of adults: Study of pathological prognostic variables and definition of a histopathological grading system. Int J Cancer 33: 37–42, 1984

    PubMed  Google Scholar 

  13. Sternberger LA: Immunocytochemistry, 2nd ed. John Wiley and Sons, New York 1979

    Google Scholar 

  14. Mantel N: Evaluation of survival data and two new Rank order statistics arising in its consideration. Cancer Chemoth Rep 50: 163–170, 1966

    Google Scholar 

  15. Harris M, Kahn MK: Phyllodes tumour and stromal sarcoma of the breast: An ultrastructural comparison. Histopathology 8: 315–330, 1984

    PubMed  Google Scholar 

  16. Ludgate CM, Anderson TJ, Langlands AO: Sarcoma of the female breast. Report of a serie of 30 cases. Clin Oncol 3: 97–105, 1977

    PubMed  Google Scholar 

  17. Van Niekerk JLM, Wobbes TH, Holland Van Haelst UJG: Malignant fibrous histiocytoma of the breast with axillary lymph node involvement. J Surg Oncol 34: 32–35, 1987

    PubMed  Google Scholar 

  18. Khanna S, Gupta S, Khanna NN: Sarcomas of the breast: Homogenous or heterogenous? J Surg Oncol 18: 119–128, 1981

    PubMed  Google Scholar 

  19. Vera-Sempere F, Llombart-Bosch A: Malignant fibrous histiocytoma (MFH) of the breast. Primary and post irradiation variants. An ultra-structural study. Pathol Res Pract 178: 289–296, 1984

    PubMed  Google Scholar 

  20. Langham MR, Mills AS, De May RM, O'Dowd GJ, Grathwohl MA, Horsley JS: Malignant fibrous histiocytoma of the breast. A case report and review of the literature. Cancer 54: 558–563, 1984

    PubMed  Google Scholar 

  21. Norris HJ, Taylor HB: Sarcomas and related mesenchymal tumours of the breast. Cancer 22: 22–28, 1968

    PubMed  Google Scholar 

  22. De Roquancourt A, Mosnier JF, Espie M, Hermouet M, Brocheriou C: Sarcome stromal du sein: deux observations. Arch Anat Cytol Path, 33: 159–164, 1985

    Google Scholar 

  23. Leader M, Collins M, Patel J, Henry K: Vimentin: an evaluation of its role as a tumor marker. Histopathology 11: 63–72, 1987

    PubMed  Google Scholar 

  24. Lawson CW, Fisher C, Gatter KC: An immunohistochemical study of differentiation in malignant fibrous histiocytoma. Histopathology 11: 375–383, 1987

    PubMed  Google Scholar 

  25. Leader M, Patel J, Collins M, Henry K: Anti-alphal-antichymotrypsin staining of 194 sarcomas, 38 carcinomas, and 17 malignant melanomas. Its lack of specificity as tumor marker. Am J Surg Pathol 11: 133–139, 1987

    PubMed  Google Scholar 

  26. Nakajima T, Watanabe S, Sato Y, Kameya T, Hirota T, Shimosato Y: An immunoperoxidase study of S100 protein distribution in normal and neoplastic tissues. Am J Surg Pathol 6: 715–727, 1982

    PubMed  Google Scholar 

  27. Roholl PJM, De Jong ASH, Ramaekers FCS: Application of markers in the diagnosis of soft tissue tumors. Histopathol 9: 1019–1035, 1985

    Google Scholar 

  28. Leader M, Collins M, Patel J, Henry K: Antineuron specific enolase staining reactions in sarcomas and carcinomas: its lack of neuroendocrine specificity. J Clin Pathol 39: 1186–1192, 1986

    PubMed  Google Scholar 

  29. Hashimoto H, Daimaru Y, Enjojii M: S100 protein distribution in liposarcoma. An immunoperoxidase study with special reference to the distinction of liposarcoma from myxoid malignant fibrous histiocytoma. Virchows Arch (A) 405: 1–10, 1984

    Google Scholar 

  30. Leader M, Collins M, Patel J, Henry K: Desmin: its value as a marker of muscle derived tumors using a commercial antibody. Virchow Arch (A) 411: 345–349, 1987

    Google Scholar 

  31. Nielsen BB: Leiomyosarcoma of the breast with late dissemination. Virchows Arch A (Pathol Anat) 403-241-245, 1984

  32. Chen KTK, Kuo T, Hoffman KD: Leiomyosarcoma of the breast. A case of long survival and late hepatic metastasis. Cancer 47: 1883–1886, 1981

    PubMed  Google Scholar 

  33. Coindre JM, Trojani M, Contesso G, David M, Rouësse J, Binh Bui N, Boddaert A, De Mascarel I, De Mascarel A, Goussot JF: Reproducibility of a histologic grading system for adult soft tissue sarcoma. Cancer 58: 306–309, 1986

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Institut Gustave-Roussy, 94805, Villejuif, France

    Ph. Terrier, M. J. Terrier-Lacombe, S. Friedman & G. Contesso

  2. U66 INSERM, Institut Gustave-Roussy, 94805, Villejuif, France

    H. Mouriesse

  3. Department of Adult Medicine, Institut Gustave-Roussy, 94805, Villejuif, France

    M. Spielmann

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  1. Ph. Terrier
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  2. M. J. Terrier-Lacombe
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  3. H. Mouriesse
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  4. S. Friedman
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  5. M. Spielmann
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  6. G. Contesso
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Terrier, P., Terrier-Lacombe, M.J., Mouriesse, H. et al. Primary breast sarcoma: A review of 33 cases with immunohistochemistry and prognostic factors. Breast Cancer Res Tr 13, 39–48 (1989). https://doi.org/10.1007/BF01806549

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