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Hyaluronan and cell locomotion

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Abstract

Hyaluronan (HA), a glycosaminoglycan, has long been implicated in cell locomotion. We have shown that HA production regulates the locomotion of H-ras-transformed cells. This autocrine motility mechanism is mediated by a novel HA receptor termed RHAMM, an acronym for Receptor for HA Mediated Motility. HA: RHAMM interactions regulate directional locomotion of tumor cells and result in enhanced protein tyrosine phosphorylation that may be a critical messenger mechanism for initiation of locomotion.

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Authors and Affiliations

  1. Monitoba Institute of Cell Biology, University of Manitoba, 100 Olivia Street, R3E 0V9, Winnipeg, Manitoba, Canada

    E. A. Turley

  2. Department of Pediatrics, University of Manitoba, 100 Olivia Street, R3E 0V9, Winnipeg, Manitoba, Canada

    E. A. Turley

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Turley, E.A. Hyaluronan and cell locomotion. Cancer Metast Rev 11, 21–30 (1992). https://doi.org/10.1007/BF00047600

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