Abstract
1. Interleukin-1 receptor antagonist (IL-1Ra), as well as the interleukin-1β (IL-1β) gene response to immobilization stress (IMS), was examined in the rat brain. The reverse transcription–polymerase chain reaction was employed to determine mRNA levels.
2. IL-1β and IL-1Ra mRNA levels peaked at approximately 0.5 and 2–4 hr, respectively. The maximum mRNA levels of IL-1β were 15-fold higher than pre-IMS levels, whereas those of IL-1Ra were 250-fold higher in the hypothalamus.
3. After the biosynthesis of IL-1β has peaked, IL-1Ra may contribute to attenuation of the IL-1 activity which has been enhanced by IMS.
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Suzuki, E., Shintani, F., Kanba, S. et al. Immobilization Stress Increases mRNA Levels of Interleukin-1 Receptor Antagonist in Various Rat Brain Regions. Cell Mol Neurobiol 17, 557–562 (1997). https://doi.org/10.1023/A:1026319107528
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DOI: https://doi.org/10.1023/A:1026319107528