Abstract
SUMMARY
1. The rapid cell death of cortical neurons in serum-free culture was rescued by the condition medium from the high-density culture, but not by brain-derived neurotrophic factor or basic fibroblast growth factor.
2. Similar rescue was observed by the addition of (−)BPAP, an impulse enhancer, and (+)-pentazocine, a sigma receptor agonist. These actions were blocked by BD1063, a sigma receptor antagonist.
3. (−)BPAP showed a weak displacement activity in the [3H]pentazocine binding to synaptic membranes from rat cerebral cortex.
4. These findings suggest that (−)BPAP and (+)-pentazocine have unique survival activity on cortical neurons through sigma receptors.
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Hamabe, W., Fujita, R., Yasusa, T. et al. (−)1-(Benzofuran-2-yl)-2-propylaminopentane Shows Survival Effect on Cortical Neurons Under Serum-Free Condition Through Sigma Receptors. Cell Mol Neurobiol 20, 695–702 (2000). https://doi.org/10.1023/A:1007050808754
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DOI: https://doi.org/10.1023/A:1007050808754