Summary
1. The separation of pentafluorophenylalanine into optical antipodes has been effected.
2. Two new analogs of oxytocin — [2-L-pentafluorophenylalanine]oxytocin and [2-D-pentafluorophenylalanine]oxytocin — have been synthesized and their uterotonic activities have been studied.
3. It has been shown that donor — acceptor interaction plays a fundamental role in the stimulation of the biological effect.
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Additional information
A. A. Zhdanov Leningrad State University. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 392–398, May–June, 1977.
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Kaurov, O.A., Smirnova, M.P. Analogs of oxytocin with L- and D-pentafluorophenylalanines in the second position. Chem Nat Compd 13, 332–336 (1977). https://doi.org/10.1007/BF00573555
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DOI: https://doi.org/10.1007/BF00573555