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Analogs of oxytocin with L- and D-pentafluorophenylalanines in the second position

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Chemistry of Natural Compounds Aims and scope

Summary

1. The separation of pentafluorophenylalanine into optical antipodes has been effected.

2. Two new analogs of oxytocin — [2-L-pentafluorophenylalanine]oxytocin and [2-D-pentafluorophenylalanine]oxytocin — have been synthesized and their uterotonic activities have been studied.

3. It has been shown that donor — acceptor interaction plays a fundamental role in the stimulation of the biological effect.

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Additional information

A. A. Zhdanov Leningrad State University. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 392–398, May–June, 1977.

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Kaurov, O.A., Smirnova, M.P. Analogs of oxytocin with L- and D-pentafluorophenylalanines in the second position. Chem Nat Compd 13, 332–336 (1977). https://doi.org/10.1007/BF00573555

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  • DOI: https://doi.org/10.1007/BF00573555

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