Abstract
Four different schemes for the synthesis by the classical method of pyroglutamylasparaginylglycine — a suggested aggression peptide have been described. The best is a scheme using C- and N-terminal protective groups of the benzyl type at the stage of obtaining the protected tripeptide. Literature information according to which the compound possesses biological activity has been refuted.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature cited
K. L. Reichelt, O. E. Trygstad, I. Foss, and J. H. Johansen, Psychopharmacology of Aggression, Raven Press, New York (1979), p. 159.
N. A. Krit, M. P. Filatova, O. V. Koval'chuk, and N. V. Beschastnaya, Bioorg. Khim.,7, No. 7, 965 (1981).
S. Mojsov, A. R. Mitchell, and R. B. Merrifield, J. Org. Chem.,45, No. 4, 555 (1980).
O. Trygstad, I. Foss, P. D. Edminson, J. H. Joansen, and K. L. Reichelt, Acta Endocrinol.,89, No. 1, 196 (1978).
D. M. Nance, D. H. Coy, and A. J. Kastin, Pharmacol. Biochim. Behav.,11, No. 6, 733 (1979); S. Bjorkman, J. -A. Karlsson, H. Sievertsson, T. Lewander, and C. J. Bowers, Acta Pharm. Suec.,17, No. 3, 130 (1980); C. J. Bauce, D. C. Elliott, R. Hughes, and H. J. Goren, Can. J. Physiol. Pharmacol.,59, No. 1, 88 (1981); U. A. Knuth, K. Spiegelburg, and H. P. C. Schneider, Acta Endocrinol.,98, No. 3, 477 (1981); D. R. K. Harding, C. A. Bishop, M. F. Tartellin, and W. S. Hancock, Int. J. Pept. Prot. Res.,18, No. 2, 214 (1981).
Additional information
A. A. Zhdanov Leningrad State University. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 253–255, March–April, 1988.
Rights and permissions
About this article
Cite this article
Sorochinskaya, E.I., Leont'eva, L.I. & Martynov, V.F. Synthesis of a suggested aggression peptide. Chem Nat Compd 24, 216–217 (1988). https://doi.org/10.1007/BF00596754
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00596754