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Metiamide in the Zollinger-Ellison syndrome

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Abstract

The histamine H2-receptor antagonist metiamide is an inhibitor of endogenous and stimulated gastric-acid secretion. It appears to have therapeutic possibilities in duodenal-ulcer disease. Three patients exhibiting the Zollinger-Ellison syndrome have been treated with this drug for six months or more. Rapid symptomatic improvement occurred in each case, followed by ulcer healing. There were also reductions in gastric secretion and consistent changes in the fasting serum-gastrin concentration. One patient relapsed temporarily during therapy. There have been no side effects. It is concluded that, in the short term, metiamide is of benefit in the Zollinger-Ellison syndrome.

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Authors and Affiliations

  1. Gastroenterology Group, Department of Physiology, The University of Newcastle upon Tyne, England

    E. L. Blair MD, FRCPEd, E. R. Grund BSc, I. T. Miller MB, BS, FRCS, J. D. Reed PhD, D. J. Sanders PhD,  M. H. Thompson MB, BS, FRCS & C. W. Venables MS, FRCS

  2. Gastroenterology Group, Department of Surgery, The University of Newcastle upon Tyne, NE1 4LP, Newcastle upon Tyne, England

    E. L. Blair MD, FRCPEd, E. R. Grund BSc, I. T. Miller MB, BS, FRCS, J. D. Reed PhD, D. J. Sanders PhD,  M. H. Thompson MB, BS, FRCS & C. W. Venables MS, FRCS

  3. Sunderland Royal Infirmary, Sunderland, Durham, England

    E. L. Blair MD, FRCPEd, E. R. Grund BSc, I. T. Miller MB, BS, FRCS, J. D. Reed PhD, D. J. Sanders PhD,  M. H. Thompson MB, BS, FRCS & C. W. Venables MS, FRCS

Authors
  1. E. L. Blair MD, FRCPEd
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  2. E. R. Grund BSc
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  3. I. T. Miller MB, BS, FRCS
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  4. J. D. Reed PhD
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  5. D. J. Sanders PhD
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  6. M. H. Thompson MB, BS, FRCS
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  7. C. W. Venables MS, FRCS
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Blair, E.L., Grund, E.R., Miller, I.T. et al. Metiamide in the Zollinger-Ellison syndrome. Digest Dis Sci 20, 1123–1130 (1975). https://doi.org/10.1007/BF01070755

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  • DOI: https://doi.org/10.1007/BF01070755

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