Abstract
Three patients, two males and one female, with asymptomatic primary sclerosing cholangitis (PSC) are described. The diagnosis was made in each case by endoscopic retrograde cholangiography after investigation of persistent elevation of the serum alkaline phosphatase. All three have remained completely well without any medical or surgical treatment for 3, 7, and 15 years, respectively, despite extensive involvement of the biliary tree. Follow-up liver biopsies in two have shown no histological evidence of progression to secondary biliary cirrhosis. PSC may occur more frequently and may follow a less severe clinical course than previously recognized.
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References
Thorpe MEC, Scheuer PJ, Sherlock S: Primary sclerosing cholangitis, the biliary tree and ulcerative colitis. Gut 8:435–448, 1967
Editorial: An unusual cholangitis. Br Med J 2:1090–1091, 1976
Krieger J, Seaman WB, Porter MR: The roentgenologic appearance of sclerosing cholangitis. Radiology 95:369–375, 1970
Warren KW, Athanassiales S, Monge JI: Primary sclerosing cholangitis. Am J Surg 111:23–38, 1966
Niebling HA: Sclerosing obliterative cholangitis. Am Surg 31:245–250, 1965
Danzi JT, Makipour H, Farmer RG: Primary sclerosing cholangitis. Am J Gastroenterol 65:109–116, 1976
Elias E, Summerfield JA, Dick R, Sherlock S: Endoscopic retrograde cholangio pancreatography in the diagnosis of jaundice associated with ulcerative colitis. Gastroenterology 67:107–111, 1974
Chapman RW, Arborgh BA, Rhodes JM, Summerfield JA, Dick R, Scheuer PJ, Sherlock S: Primary sclerosing cholangitis—a review of its clinical features, cholangiography and hepatic histology. Gut 21:870–877, 1980
Dew MJ, Thompson H, Allan RN: The spectrum of hepatic dysfunction in inflammatory bowel disease. Q J Med 48:113–135, 1979
Blackstone MO, Nemchausky BA: Cholangiographic abnormalities in ulcerative colitis associated pericholangitis which resemble sclerosing cholangitis. Am J dig Dis 23:579–585, 1978
Ritchie JK, Allan RN, Macartney J, Thompson M, Hawley PR, Cooke WT: Biliary tract carcinoma associated with ulcerative colitis. Q J Med 43:263–279, 1974
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Chapman, R.W.G., Burroughs, A.K., Bass, N.M. et al. Long-standing asymptomatic primary sclerosing cholangitis report of three cases. Digest Dis Sci 26, 778–782 (1981). https://doi.org/10.1007/BF01309608
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DOI: https://doi.org/10.1007/BF01309608