Skip to main content
SpringerLink
Log in

The influence of acute or chronic nicotine treatment on ethanol-induced gastric mucosal damage in rats

  • Original Articles
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

The influences of acute or chronic nicotine pretreatment on ethanol-induced changes on gastric secretion, mucosal blood flow (GMBF), and glandular mucosal damage were studied in anesthetized rats. Ethanol administration decreased gastric acid secretion and GMBF, which were accompanied by a marked increase in gastric mucosal damage. Acute nicotine incubation 2 or 4 mg dose-dependently elevated both the titratable acid in the luminal solution and the gastric secretory volume; it also prevented the depressive action on GMBF and gastric mucosal damage in ethanol-treated animals. Chronic nicotine treatment for 10 days reduced the inhibitory action of ethanol on gastric acid secretion; the higher dose (25 μg/ml drinking water) potentiated the decrease of GMBF and the ulcerogenic property of ethanol. However, chronic treatment with the lower dose (5 μg/ml drinking water) had the opposite effects; it also markedly increased the gastric secretory volume. It is concluded that acute nicotine pretreatment elevates, whereas chronic nicotine pretreatment differentially affects GMBF. These effects could account for their protective or preventive actions on ethanol ulceration. The increase in nonacid gastric secretory volume by nicotine could partially explain its antiulcer effect. Furthermore, the acid secretory state of the stomach appears unrelated to the ulcerogenic property of ethanol.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bennett JR: Smoking and the gastrointestinal tract. Gut 13:658–665, 1972

    PubMed  Google Scholar 

  2. Harrison AR, Elashoff JD, Grossman MI: Cigarette smoking and ulcer disease.In Smoking and Health, A Report of the Surgeon General. Washington, DC, DHEW publication No. 79-50066, 1979, pp 9.3–9.21

  3. Doll R, Jones FA, Pygott F: Effect of smoking on the production and maintenance of gastric and duodenal ulcers. Lancet 1:657–662, 1958

    PubMed  Google Scholar 

  4. Korman MG, Shaw RG, Hansky J, Schmidt GT, Stern AI: Influence of smoking on healing rate of duodenal ulcer in response to cimetidine or high-dose antacid. Gastroenterology 81:1451–1453, 1981

    Google Scholar 

  5. Jaffe JH: Drug addiction and drug abuse.In The Pharmacological Basis of Therapeutics. AG Gilman, LS Goodman, TW Rall, F Murad (eds). New York, Macmillan, 1985, pp 532–581

    Google Scholar 

  6. Cooke AR: Drugs and gastric damage. Drugs 11:36–44, 1976

    PubMed  Google Scholar 

  7. Ogle CW, Cho CH, Wong SH: The effect of nicotine on ethanol-induced gastric ulcers in rats. Experientia 41:1140–1141, 1985

    PubMed  Google Scholar 

  8. Wong SH, Ogle CW, Cho CH: The influence of chronic or acute nicotine pretreatment on ethanol-induced gastric ulceration in the rat. J Pharm Pharmacol 38:537–540, 1985

    Google Scholar 

  9. Guth PH: Gastric blood flow in ethanol injury and prostaglandin cytoprotection. Scand J Gastroenterol 21(Suppl. 125):86–91, 1986

    Google Scholar 

  10. Oates PJ, Hakkinen JP: Studies on the mechanism of ethanol-induced gastric damage in rats. Gastroenterology 94:10–21, 1988

    PubMed  Google Scholar 

  11. Szabo S, Trier JS, Brown A, Schnoor J: Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology 88:228–236, 1985

    PubMed  Google Scholar 

  12. Albinus M, Frisch G, Klein S: The effects of nicotine on basal and stimulated gastric secretions in the conscious cat and in isolated guinea pig gastric mucosal cells. Agents Actions 23:289–292, 1988

    PubMed  Google Scholar 

  13. Cho CH, Wong SH, Ogle CW, Enoveso OV: The effects of gastric secretagogues on ethanol ulceration in rat stomachs. IRCS Med Sci 13:627–628, 1985

    Google Scholar 

  14. Kivilaakso E, Fromm D, Silen W: Effect of the acid secretory state on intramural pH of rabbit gastric mucosa. Gastroenterology 75:641–648, 1978

    PubMed  Google Scholar 

  15. Smith P, O'Brien P, Fromm D, Silen W: Secretory state of gastric mucosa and resistance to injury by exogenous acid. Am J Surg 133:81–85, 1977

    PubMed  Google Scholar 

  16. Wong SH, Cho CH, Ogle CW: The influence of omeprazole on the protective effects of secretagogues against ethanol-induced gastric ulceration in rats. Eur J Pharmacol 141:453–459, 1987

    PubMed  Google Scholar 

  17. Mersereau WWA, Hinchey EJ: Effect of gastric acidity on gastric ulceration induced by hemorrhage in the rat, utilizing a gastric chamber technique. Gastroenterology 64:1130–1135, 1973

    PubMed  Google Scholar 

  18. Wong SH, Cho CH, Ogle CW: Protection by zinc sulphate against ethanol-induced mucosal barrier. Pharmacology 33:94–102, 1986

    PubMed  Google Scholar 

  19. Shepherd AP, Riedel GL: Continuous measurement of intestinal mucosal blood flow by laser-Doppler velocimetry. Am J Physiol 242:G668-G672, 1982

    PubMed  Google Scholar 

  20. Cho CH, Pang SF, Chen BW, Pfeiffer CJ: Modulating action of melatonin on serotonin-induced aggravation of ethanol ulceration and changes of mucosal blood flow in rat stomachs. J Pineal Res 6:89–97, 1989

    PubMed  Google Scholar 

  21. Sonnenberg A, Husmert N: Effect of nicotine on gastric mucosal blood flow and acid secretion. Gut 23:532–535, 1982

    PubMed  Google Scholar 

  22. Grayson J, Oyebola DDO: Effect of nicotine on blood flow, oxygen consumption and glucose uptake in the canine small intestine. Br J Pharmacol 85:797–804, 1985

    PubMed  Google Scholar 

  23. Robert ME, Leung FW, Guth PH: Nicotine and smoking do not decrease basal gastric mucosal blood flow in anesthetized rats. Dig Dis Sci 31:530–534, 1986

    PubMed  Google Scholar 

  24. Javis LR, Whitehead R: Effect of nicotine on the morphology of the rat gastric mucosa. Gastroenterology 78:1488–1494, 1978

    Google Scholar 

  25. Moody PM, Griffith RB, Averitt JH:In Proceedings of the University of Kentucky Tobacco and Health Research Institute. Tobacco and Health Workshop Conference. Conference Reports 3. Lexington, Kentucky, 1972

  26. Cho CH, Ogle CW, Wong SH, Lam SK: The effects of ethanol and nicotine on gastrin and somatostatin release in rats. Horm Res 25:113–119, 1987

    PubMed  Google Scholar 

  27. Kvietys PR, Morgan Smith S, Grisham MB, Manci EA: 5-Aminosalicylic acid protects against ischemia/reperfusion-induced gastric bleeding in the rat. Gastroenterology 94:733–738, 1988

    PubMed  Google Scholar 

  28. Perry MA, Wadhwa S, Parks DA, Pickard W, Granger DN: Role of oxygen radicals in ischemia-induced lesions in the cat stomach. Gastroenterology 90:362–367, 1986

    PubMed  Google Scholar 

  29. Ronne IA, Nielsen H: The antiinflammatory moiety of sulfasalazine, 5-aminosalicylic acid, is a radical scavenger. Agents Actions 21:191–194, 1987

    PubMed  Google Scholar 

  30. Cho CH, Ogle CW, Wong SH, Koo MWL: Effects of zinc sulphate on ethanol- and indomethacin-induced ulceration and changes in prostaglandin E2 and histamine levels in the rat gastric glandular mucosa. Digestion 32:288–295, 1985

    PubMed  Google Scholar 

  31. Nosalova V, Zaviacic M, Jakubovsky, Babulova A, Polak S: Gastroprotective effect of pentacaine: Role of mast cells. Agents Actions 23:283–285, 1988

    PubMed  Google Scholar 

  32. Peskar BM, Lange K, Hoppe U, Peskar BA: Ethanol stimulates formation of leukotriene C4 in the rat gastric mucosa. Prostaglandins 31:283–293, 1986

    PubMed  Google Scholar 

  33. Chiu PJS, Vemulpalli S, Barnett A: Lysosomal enzyme release and ethanol-induced gastric lesions in rats. J Pharm Pharmacol 35:121–123, 1983

    PubMed  Google Scholar 

  34. Cho CH, Pfeiffer CJ, Cheema A: Studies of zinc and histamine on lysosomal fragility: Possible role in stress ulceration. Pharmacol Biochem Behav 13:41–44, 1980

    Google Scholar 

  35. Nagata M, Okuma Y, Osumi Y: Nicotine applied into the dorsal motor nucleus of the vagus inhibits enhanced gastric acid output and mucosal blood flow in rats. Eur J Pharmacol 121:313–318, 1986

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, Faculty of Medicine, University of Hong Kong, Hong Kong

    C. H. Cho PhD, B. W. Chen MD, W. M. Hui MD & S. K. Lam MD

  2. Department of Pharmacology, Faculty of Medicine, University of Hong Kong, Hong Kong

    C. H. Cho PhD, B. W. Chen MD, W. M. Hui MD & S. K. Lam MD

Authors
  1. C. H. Cho PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. W. Chen MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. M. Hui MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. K. Lam MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cho, C.H., Chen, B.W., Hui, W.M. et al. The influence of acute or chronic nicotine treatment on ethanol-induced gastric mucosal damage in rats. Digest Dis Sci 35, 106–112 (1990). https://doi.org/10.1007/BF01537231

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01537231

Key words

Search

Navigation