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Systemic treatment with recombinant human epidermal growth factor accelerates healing of sclerotherapy-induced esophageal ulcers and prevents esophageal stricture formations in pigs

  • Liver: Infections, Inflammatory, And Metabolic Disorders
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Abstract

Human epidermal growth factor (EGF), a small polypeptide (6 kDa) with mitogenic properties, has been implicated in the protection of gastrointestinal mucosal integrity. The efficacy of EGF in the prevention and healing of sclerotherapy-induced esophageal lesions was investigated in 24 minipigs with surgically induced portal hypertension. In addition, the effect of EGF on intragastric acidity and pharmacokinetics was investigated as possible means to explain its protective mechanism of action. The animals underwent three weekly sessions of sclerotherapy with polidocanol 2% and were concomitantly and for an additional three weeks treated with either placebo or EGF administered paravenously in the esophagus and/or subcutaneously. The subcutaneous treatment with EGF significantly (P<0.05) reduced esophageal stricture and scar formations associated with sclerotherapy. Gastric pH values were significantly (P<0.01) elevated only in animals receiving subcutaneous injections of EGF. Furthermore, the subcutaneous administration of EGF was associated with unexpected prolonged plasma concentration of the peptide. These results suggest a possible clinical value of EGF as an adjunctive treatment with the sclerotherapy.

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Authors and Affiliations

  1. Department of Clinical Biochemistry, University Hospital of Aarhus, Section KH, Denmark

    Claus Orloff Juhl MD, Lars Vinter-Jensen MD, Lone Susanne Jensen MD, Dr Med Sci, Ebba Nexø MD, Dr Med Sci, Jens Christian Djurhuus MD, Dr Med Sci & Esam Zapher Dajani PhD

  2. International Drug Development Consultants, a Division of Mid Gulf, U.S.A., Inc., Chicago, Illinois

    Claus Orloff Juhl MD, Lars Vinter-Jensen MD, Lone Susanne Jensen MD, Dr Med Sci, Ebba Nexø MD, Dr Med Sci, Jens Christian Djurhuus MD, Dr Med Sci & Esam Zapher Dajani PhD

  3. Institute of Experimental Clinical Research, University Hospital of Aarhus, Section Skejby, DK-8000, Aarhus C, Denmark

    Claus Orloff Juhl MD, Lars Vinter-Jensen MD, Lone Susanne Jensen MD, Dr Med Sci, Ebba Nexø MD, Dr Med Sci, Jens Christian Djurhuus MD, Dr Med Sci & Esam Zapher Dajani PhD

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  1. Claus Orloff Juhl MD
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  2. Lars Vinter-Jensen MD
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  3. Lone Susanne Jensen MD, Dr Med Sci
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  4. Ebba Nexø MD, Dr Med Sci
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  5. Jens Christian Djurhuus MD, Dr Med Sci
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  6. Esam Zapher Dajani PhD
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Additional information

This study was partially funded from Gastrone Corporation, Menlo Park, California; and the Institute of Experimental Clinical Research, Aarhus, Denmark.

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Juhl, C.O., Vinter-Jensen, L., Jensen, L.S. et al. Systemic treatment with recombinant human epidermal growth factor accelerates healing of sclerotherapy-induced esophageal ulcers and prevents esophageal stricture formations in pigs. Digest Dis Sci 39, 2671–2678 (1994). https://doi.org/10.1007/BF02087708

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  • DOI: https://doi.org/10.1007/BF02087708

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