Abstract
The hyperemia at the duodenal ulcer margin is important for ulcer healing. We studied the effect of tobacco cigarette smoke on the hyperemia at the margin of mepirizole-induced duodenal ulcer. Duodenal mucosal blood flow values measured by iodo[14C]antipyrine (IAP) autoradiography and hydrogen gas clearance (HGC) were compared. Twenty-four hours after rats were injected with an ulcerogenic dose of mepirizole, they were exposed to tobacco cigarette smoke and duodenal mucosal blood flow was measured by IAP autoradiography. There is a significant correlation between the blood flow measurements by HGC and IAP autoradiography. The hyperemia at the ulcer margin previously demonstrated in our laboratory is absent after exposure of the rats to tobacco cigarette smoke. We speculate that the inhibition of ulcer margin hyperemia could explain the aggravation of duodenal ulcer by tobacco cigarette smoke.
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Harrison AR, Elashoff JD, Grossman MI: Cigarette smoking and ulcer disease.In Smoking and Health, A Report of the Surgeon General. Washington, DC, DHEW publication No. 79-50066, 1979, pp 9.3–9.21
Gugler R, Rohner HG, Kratochvil P, Brandstatter G, Schmitz H: Effect of smoking on duodenal ulcer healing with cimetidine and oxmetidine. Gut 23:866–871, 1982
Ippoliti A, Elashoff J, Valenzula J, Cano R, Frankl H, Samloff M, Koretz R: Recurrent ulcer after successful treatment with cimetidine or antacid. Gastroenterology 85:875–880, 1983
Korman MG, Hansky J, Eaves ER, Schmidt GT: Influence of cigarette smoking on healing and relapse in duodenal ulcer disease. Gastroenterology 85:871–874, 1983
Sonnenberg A, Muller-Lissner SA, Vogel E, Schmid P, Gonvers JJ, Peter P, Strohmeyer G, Blum AL: Predictors of duodenal ulcer healing and relapse. Gastroenterology 81:1061–1067, 1981
Sontag S, Graham DY, Belsito A, Weiss J, Farley A, Grunt R, Cohen N, Kinnear D, Davis W, Archambault A, Achord J, Thayer W, Gillies R, Sidorov J, Sabesin SM, Dyck W, Fleshler B, Cleator I, Wenger J, Opekun A Jr: Cimetidine, cigarette smoking, and recurrence of duodenal ulcer. N Engl J Med 311:689–693, 1984
Toon RW, Cross FS, Wangensteen OH: Effect of inhaled cigarette smoke on production of peptic ulcer in the dog. Proc Soc Exp Biol 77:866–869, 1951
Zhang XY, Leung FW: Cigarette smoke aggravates acid-induced duodenal mucosal damage in rat—role of mesenteric vasoconstriction. Scand J Gastroenterol 29:214–218, 1994
Leung FW, Reedy TJ, Van Deventer GM, Guth PH: Reduction in the index of oxygen saturation at the margin of active duodenal ulcers may lead to slow healing. Dig Dis Sci 34:417–423, 1989
Leung FW, Wong NW, Lau J, Bondoc EM, Hsu R, Leung JWC: Role of blood flow at the ulcer margin in the healing of duodenal ulcers. Gastrointest Endosc 40:334–341, 1994
Scremin OU, Leung FW, Guth PH: Pathogenesis of duodenal ulcer in the rat: Dissociation of acid load and blood flow. Am J Physiol 256:G1058-G1062, 1989
Dugas MC, Wechsler RL: Validity of iodoantipyrine clearance for measuring gastrointestinal tissue blood flow. Am J Physiol 243:G155-G171, 1982
Robert A, Nezamis JE, Lancaster C, Hanchar AJ: Cytoprotection by prostaglandins in rats—prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology 77:433–443, 1979
Hudson DM, Scremin OU, Guth PH: Measurement of regional gastroduodenal blood flow with iodo[14C]antipyrine autoradiography. Am J Physiol 248:G539-G544, 1985
Leung FW: Comparison of duodenal blood flow by hydrogen gas clearance and laser Doppler flowmetry. Scand J Gastroenterol 25:429–434, 1990
Leung FW, Morishita T, Livingston EH, Reedy T, Guth PH: Reflectance spectrophotometry for the assessment of gastroduodenal mucosal perfusion. Am J Physiol 252:G797-G804, 1987
Livingston EH, Reedy T, Leung FW, Guth PH: Computerized curve fitting in the analysis of hydrogen gas clearance curves. Am J Physiol 257:G668-G675, 1989
Pique JM, Leung FW, Tan HW, Livingston E, Scremin OU, Guth PH: Gastric mucosal blood flow response to stimulation and inhibition of gastric acid secretion. Gastroenterology 95:642–650, 1988
Endoh K, Kauffman GL Jr, Leung FW: Mechanism of aggravation of mucosal injury by intravenous nicotine in rat stomach. Am J Physiol 261:G1037-G1042, 1991
Endoh K, Kao J, Domek MJ, Leung FW: Mechanism of gastric hyperemia induced by intragastric hypertonic saline in rats. Gastroenterology 104:114–121, 1993
Robert ME, Leung FW, Guth PH: Nicotine and smoking do not decrease basal gastric mucosal blood flow in anesthetized rats. Dig Dis Sci 31:530–534, 1986
Kamada T, Kawano S, Sato N, Fukuda M, Fusamoto H, Abe H: Gastric mucosal blood distribution and its changes in the healing process of gastric ulcer. Gastroenterology 84:1541–1546, 1994
Fukotomi H, Miyamoto J, Sakita T: Endoscopical measurement of gastric blood flow of patients suffering from gastric ulcer.In Basic aspects of Microcirculation, Proceedings of the Tokyo International Symposium on Microcirculation. M. Tsuchiya, M Asano, M Oda (eds). Amsterdam, Excerpta Medica, 1981, pp 251–256
Hirose H, Takeuchi K, Okabe S: Effect of indomethacin on gastric mucosal blood flow around acetic acid-induced gastric ulcers in rats. Gastroenterology 100:1259–1265, 1991
Iwata F, Leung FW: Tobacco cigarette smoke aggravates gastric ulcer in rats by attenuation of ulcer margin hyperemia. Am J Physiol 268:G153-G160, 1995
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This work was supported by Veterans Administration Medical Research Funds, and in part by research grant (1RT 80) provided by the Cigarette and Tobacco Surtax Fund of the State of California through the Tobacco-Related Disease Research Program of the University of California.
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Iwata, F., Scremin, O.U. & Leung, F.W. Tobacco cigarette smoke attenuates duodenal ulcer margin hyperemia in the rat. Digest Dis Sci 40, 1112–1117 (1995). https://doi.org/10.1007/BF02064208
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DOI: https://doi.org/10.1007/BF02064208