Skip to main content
SpringerLink
Log in

Antiarthritic synergism of combined oral and parenteral chrysotherapy

I. Studies in adjuvant-induced arthritis in rats

  • Original Articles
  • Published:
Inflammation Aims and scope Submit manuscript

Abstract

In comparative clinical studies of auranofin (AF, oral gold) and parenteral gold in the treatment of rheumatoid arthritis, no difference in efficacy was detected. Since the pharmacologic profiles of these compounds are different, we studied their combined effect on adjuvant arthritis (AA). The effect of AF alone and combined with gold sodium thiomalate (GTM) or gold sodium thiosulfate (GTS) on the excretion of urinary hydroxyproline (UHP) and urinary calcium (UCa), and the articular index of arthritic rats was followed during five weeks of treatment. The excretion of UHP and UCa was significantly inhibited (P<0.005) in rats treated with AF combined with GTM or GTS as compared with animals treated with the individual gold compounds. However, the articular index only decreased significantly (P<0.02) in the group of rats treated with AF + GTS. The present studies open the possibility that combined treatment with oral and injectable gold provide a new approach for chrysotherapy with an increased antiarthritic potency.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Finkelstein, A. E., D. T. Walz, V. Batista, M. Mizraji, F. R. Roisman, andA. Misher. 1976. Auranofin. New oral gold compound for the treatment of rheumatoid arthritis.Ann. Rheum. Dis. 35:251–257.

    Google Scholar 

  2. Bldget, C. R., Jr., A. M. Hener, andG. T. Pietrusko. 1984. Auranofin: A unique oral chrysotherapeutic agent.Sem. Arthritis Rheum. 12:255–273.

    Google Scholar 

  3. Horton, R. J. 1983. Comparative safety and efficacy of auranofin and parenteral gold compounds: A review.Scand. J. Rheumatol. Suppl. 51:100–110.

    Google Scholar 

  4. Finkelstein, A. E., O. R. Burrone, D. T. Walz, andA. Misher. 1977. Effect of auranofin on DNA and protein synthesis in human lymphocytes.J. Rheum. 4:245–251.

    Google Scholar 

  5. Finkelstein, A. E., F. R. Roisman, andD. T. Walz. 1977. Effect of auranofin, anew antiarthritic agent on immune-complex-induced release of lysosomal enzymes from human leukocytes.Inflammation 2:143–150.

    Google Scholar 

  6. Golding, S. E., andH. E. Jasin. 1985. Arthritis and autoimmunity in animals.In Arthritis and Allied Conditions, 10th ed. D. T. McCarthy, Jr., editor. Lea and Febiger, Philadelphia. 415–430.

    Google Scholar 

  7. Orloff, S., V. Rao, andL. Verbruggen. 1979. Urinary excretion of hydroxyproline and hydroxylysyl glycosides in adjuvant induced arthritis.Ital. J. Biochem. 283:173–182.

    Google Scholar 

  8. Kivirikko, K., O. Laitinen, andS. Rockop. 1967. Modification of a specific assay for hydroxyproline in urine.Ann. Biochem. 19:249.

    Google Scholar 

  9. Henry, R. S. 1964. Clinical Chemistry, Principles and Techniques. Harper and Row, New York.

    Google Scholar 

  10. Farley, J. R., C. H. Chesnut, andA. J. Baylink. 1981. Improved method for quantative determination in serum of alkaline phosphatase of skeletal origin.Clin. Chem. 27:2002.

    Google Scholar 

  11. Kivirikko, K. I. 1970.Int. Rev. Conn. Tissue Res. 5:93.

    Google Scholar 

  12. Lorber, A., R. L. Cohen, C. Chang, andH. Anderson. 1968. Gold determination in biological fluids by atomic absortion spectrometry application to chrysotherapy in rheumatoid arthritis patients.Arthritis Rheum. 11:170–177.

    Google Scholar 

  13. Sloboda, A. E., J. E. Berenbaum, L. A. Oronsky, andS. S. Kerwar. 1981. Studies on type II collagen-induced polyarthritis in rats.Arthritis Rheum. 24:616–624.

    Google Scholar 

  14. Walz, D. T., M. J. DiMartino, andA. Misher. 1971. Suppression of adjuvant-induced arthritis in the rat by gold sodium.Ann. Rheum. Dis. 30:303–306.

    Google Scholar 

  15. Walz, D. T., M. T. DiMartino, L. W. Chakrin, B. M. Sulton, andA. Misher. 1976. Antiarthritic properties and unique pharmacological profile of a potential chrysotherapeutic agent: SK&F D-39162.J. Pharmacol. Exp. Ther. 197:142–152.

    Google Scholar 

  16. Garret, I. R., M. W. Whitehouse, B. Vernon-Roberts, andP. M. Brooks. 1986. Ambivalent properties of gold drugs in adjuvant-induced polyarthritis in rats.J. Rheumatol. 12:1079–1082.

    Google Scholar 

  17. Sutton, R. A. 1983. Disorders of renal calcium excretion.Kidney Int. 23:665–673.

    Google Scholar 

  18. Gofton, J. P., andW. M. O'brien. 1982. Effects of auranofin on the radiological progression of joint erosion in rheumatoid arthritis.J. Rheumatol. (Suppl. 8)9:169–172.

    Google Scholar 

  19. Manicourt, D., S. Orloff, andV. Rao. 1979. Synovial fluid and serum hydroxyproline fractions in rheumatoid arthritisScand.J. Rheumatol. 8:161–167.

    Google Scholar 

  20. Finkelstein, A. E., F. R. Roisman, V. Batista, F. G. DeNudelman, E. H. DeTitto, M. Mizraji andD. T. Walz. 1980. Oral chrysotherapy in rheumatoid arthritis: Minimum effective dose.J. Rheumatol. 7:160–168.

    Google Scholar 

  21. Snyder, R. M., C. K. Mirabelli, andS. T. Crooke. 1986. Cellular association, intracellular distribution and efflux of auranofin via sequential ligand exchange reactions.Biochem. Pharmacol. 35:923–932.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Rheumatology-Immunology, Albert Einstein Research Medical Center, (Fundación CIMAE), Buenos Aires, Argentina

    Abraham E. Finkelstein, Martha Ladizesky & Elisa Kohn

  2. Department of Oral Biology, The Hebrew University-Hadassah Faculty of Dental Medicine, Jerusalem, Israel

    Ruth Borinsky & Isaac Ginsburg

Authors
  1. Abraham E. Finkelstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Martha Ladizesky
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ruth Borinsky
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Elisa Kohn
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Isaac Ginsburg
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This study was supported by a Dr. Martine and Harry Recanati Biomedical Research Grant of Ralli Financial Agency SA, Geneva, Switzerland; a grant from Dr. S. M. Robbins of Cleveland, Ohio; and from the Chief Scientist, Ministry of Health, Government of Israel.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Finkelstein, A.E., Ladizesky, M., Borinsky, R. et al. Antiarthritic synergism of combined oral and parenteral chrysotherapy. Inflammation 12, 373–382 (1988). https://doi.org/10.1007/BF00915772

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00915772

Keywords

Search

Navigation