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The Role of Stroma in Breast Carcinoma Growth In Vivo

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Journal of Mammary Gland Biology and Neoplasia Aims and scope Submit manuscript

Abstract

The malignant progression of tumors is thoughtto be related to the expression of oncogenes and loss ofexpression of tumor suppressor gene. These factors areintrinsic to the cancer cells themselves. However, carcinomas are also infiltrated by host cells(fibroblasts, endothelial cells, inflammatory cells) andsurrounded by an extracellular matrix which isextensively remodeled. The extracellular matrixcomponents and infiltrating host cells provide amicroenvironment that conditions both tumor progressionand the metastatic process. Transplantation of humantumors into athymic nude mice has become an importantexperimental approach to study the biology of human cancers.The different models developed so far are beginning toelucidate the role of matrix molecules, growth factorsand enzymes as well as fibroblasts in tumor progression. These animal models are likely toprovide a useful tool to evaluate new antitumortreatments.

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  1. Agnes Noel
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  2. Jean-Michel Foidart
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Noel, A., Foidart, JM. The Role of Stroma in Breast Carcinoma Growth In Vivo. J Mammary Gland Biol Neoplasia 3, 215–225 (1998). https://doi.org/10.1023/A:1018703208453

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