Abstract
The need for objective design of pharmacokinetic experiments aimed at model discrimination is argued. A sequential design strategy based on information theory is outlined. The characteristics of this strategy and its applicability to pharmacokinetic experiments is examined by means of computer simulated experiments. The limitations of the technique are discussed and alternative approaches outlined.
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This work was supported by the Medical Research Council of Ireland.
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Lacey, L., Dunne, A. The design of pharmacokinetic experiments for model discrimination. Journal of Pharmacokinetics and Biopharmaceutics 12, 351–365 (1984). https://doi.org/10.1007/BF01061725
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DOI: https://doi.org/10.1007/BF01061725