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Control of growth in neonatal pig hearts

  • Cellular Function and Metabolism
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Molecular and Cellular Biochemistry Aims and scope Submit manuscript

Abstract

The pig heart grows at a maximal rate in the first 2–3 days of life due to a volume overload imposed on the heart at birth. Rates of ribosome formation and protein synthesis cannot be further accelerated duringin vitro perfusion with agents that increase cyclic AMP, that bind to α1-adrenergic receptors or that bind to angiotensin II receptors. Growth of the heartin vivo can be restrained by treatment with an angiotensin-converting enzyme inhibitor, enalapril maleate, or an angiotensin receptor antagonist, DuP 753. In the enalapril-treated heart, norepinephrine plus propranolol, but not angiotensin II, accelerated ribosome formation. Rapid growth of the left ventricle of pig heart during the first 10 days of life is due largely to eccentric hypertrophy.

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Authors and Affiliations

  1. Geisinger Clinic, Sigfried and Janet Weis Center for Research, 17822-2601, Danville, PA, USA

    Cathy J. Beinlich & Howard E. Morgan (Senior Vice President for Research)

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  1. Cathy J. Beinlich
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  2. Howard E. Morgan
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Beinlich, C.J., Morgan, H.E. Control of growth in neonatal pig hearts. Mol Cell Biochem 119, 3–9 (1993). https://doi.org/10.1007/BF00926846

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