Summary
Two molecular forms of topoisomerase I differing in size and sensitivity to camptothecin were isolated from calf thymus. Mapping of topo I cleavage sites of the cloned chicken αA-globin and human c-Ha-ras genes was carried out. Camptothecin was shown to affect site specificity of the topoisomerases.
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Bronstein, I.B., Gromova, I.I. & Razin, S.V. Specific cleavage of chicken αA-globin and human c-Ha-ras genes by two molecular forms of calf thymus topoisomerase I. Mol Cell Biochem 101, 115–124 (1991). https://doi.org/10.1007/BF00229529
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DOI: https://doi.org/10.1007/BF00229529