Summary
Thirty patients with recurrent primary brain tumors were treated with a combination of 5-fluorouracil and leucovorin. There were three responses seen. Toxicity consisted of stomatitis, diarrhea, and hematological suppression. 5-fluorouracil and leucovorin would appear to be minimally effective in recurrent brain tumors.
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Kornblith PL, Walker MD, Cassady JR: Chemotherapy of high-grade astrocytomas, Neurologic Oncology, 1987, eds 130–149
Edland RW, Javid M, Ansfield FJ: Glioblastoma multiforme: an analysis of the results of postoperative radiotherapy alone versus radiotherapy and concomitant 5-fluorouracil (a prospective randomized study of 32 cases). Am J Roentgenol Radium Ther Nucl Medication 111: 337–342, 1971
Poon MA, O'Connell MJ, Moertel CG, Wieand HS, Cullinan SA, Everson LK, Krook JE, Mailliard JA, Laurie JA, Tschetter LK, Wiesenfeld M: Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma. J Clin Oncol 7: 1407–1417, 1989
Shapiro WR, Green SB, Burgh PC, Selker RG, VanGilder JC, Robertson JT, Mealey Jr. J, Ransohoff J, Mahaley Jr. SM: A randomized comparison of intra-arterial versus intravenous BCNU, with or without intravenous 5-fluorouracil, for newly diagnosed patients with malignant glioma. J Neurosurg 76: 772–781, 1992
Greenberg HS, Chandler WF, Ensminger WD, Junck L, Thornton A, Sandler H, Page MA, McKeever P, Gebarski S, Liang B, Tankanow R: Radiosensitization with carotid arterial infusion of bromodeoxyuridine (BUDR)+/− 5-fluorouracil (5FU) biomodulation with focal external beam radiation (FEBT) for malignant gliomas. Dev-Oncol 66: 217–219, 1991
Levin VA, Phuphanich S, Liou HC, DaSilva V, Murovic J, Choucair A, Chamberlain M, Berger M, Seager M, Davis RL, Silver P, Gutin PH, Wilson CB: Phase II study of combined carmustine, 5-fluorouracil, hydroxyurea, and 6-mercaptopurine (BFHM) for the treatment of malignant gliomas. Cancer Treat Rep 70: 1271–1274, 1986
Rodriguez LA, Prados M, Fulton D, Edwards MSB, Silver P, Levin V: Treatment of recurrent brain stem gliomas and other central nervous system tumors with 5-fluorouracil, CCNU, hydroxyurea, and 6-mercaptopurine. Neurosurgery 22(4): 691–693, 1988
Yung WK, Gleason MJ, Levin VA: Continuous infusion carboplatin and 5FU followed by procarbazine in patients with recurrent malignant gliomas (meeting abstract). Proc-Annu-Meet-Am-Soc-Clin-Oncol 10: A376, 1991
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This study was conducted as a collaborative trial of North Central Cancer Treatment Group and Mayo Clinic and was supported in part by Public Health Service grants CA-25224, CA-37404, CA-15083, CA-35113, CA-52352, CA-37417, CA-35448, CA-35269, CA-35101, CA-35195, and CA-35103 from the National Cancer Institute, Department of Health and Human Services. Additional participating institutions include: Quain and Ramstad Clinic, Bismarck ND 58502 (Delano M. Pfeifle, M.D.); Carle Cancer Center Community Clinical Oncology Program, Urbana, IL 61801 (Alan K. Hatfield, M.D.); Grand Forks Clinic, Ltd., Grand Forks, ND 58201 (John A. Laurie, M.D.); Nebraska Oncology Group - Creighton University, University of Nebraska Medical Center, and Associates, Omaha, NE 68131 (James A. Mailliard, M.D.); Siouxland Hematology-Oncology Associates, Sioux City, IA 51105 (John C. Michalak, M.D.); and The St. Cloud Clinic of Internal Medicine, Ltd., St. Cloud, MN 56301 (Harold E. Windschitl, M.D.)
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Cascino, T.L., Veeder, M.H., Buckner, J.C. et al. Phase II study of 5-fluorouracil and leucovorin in recurrent primary brain tumor. J Neuro-Oncol 30, 243–246 (1996). https://doi.org/10.1007/BF00177275
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DOI: https://doi.org/10.1007/BF00177275