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Contribution of a humoral factor to postsynaptic sensitization in heterosynaptic facilitation

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Abstract

It was shown that heterosynaptic facilitation develops in the cerebral ganglia giant neurons of the freshwater gastropod molluskPlanorbis corn eus due to diffuse neurohumoral influences on pre- and postsynaptic structures and not local synaptic action on presynaptic mechanisms. It was also found that n-cholinergic synaptic mechanisms come under this facilitatory influence. Serotonin is the source of facilitation in neurons of bothPlanorbis corneus cerebral ganglion and those of the aplysia abdominal ganglion. Seeing that: a) conditioning stimuli facilitate the effects produced by iontophoretic acetylcholine application, as well as n-cholinergic synaptic transmission and b) the amplitude of EPSP and acetylcholine potential increase 4–6 times during facilitation when the input impedance of the post-synaptic membrane is increased by just 20%, it was deduced that the postsynaptic membrane of the giant neuron makes a significant contribution to heterosynaptic facilitation of the sensitization of n-cholinergic receptors. The part played by n-cholinergic receptors of the postsynaptic membrane in heterosynaptic facilitation and conditioned reflex habituation is discussed.

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Authors
  1. V. M. Storozhuk
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  2. I. N. Antonov
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Additional information

A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Neirofiziologiya, Vol. 18, No. 2, pp. 250–259, March–April, 1986.

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Storozhuk, V.M., Antonov, I.N. Contribution of a humoral factor to postsynaptic sensitization in heterosynaptic facilitation. Neurophysiology 18, 191–198 (1986). https://doi.org/10.1007/BF01052369

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  • DOI: https://doi.org/10.1007/BF01052369

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