Abstract
A new subdivision, the “marginal division” (MrD), was discovered at the caudal border of the striatum and surrounds the rostral edge of the globus pallidus in the rat brain in our previous studies. The neuronal somata of the MrD are mostly fusiform in shape with their long axes lining dorsoventrally. The MrD is more densely filled with substance P (SP)-, Leucine-enkephalin (L-Enk)-, dynorphin B-, neurotensin-, somatostatin- and cholecystokinin (CCK)-immunoreactive fibers and terminal-like structures than the rest of the striatum. The MrD was confirmed in the cat neostriatum as well. The present study intended to explore whether the MrD exists in the monkey neostriatum (putamen) with Nissl, histochemical and immunohistochemical methods. A band of fusiform neurons were obviously identified at the caudomedial edge of the putamen. These neurons lie outside the lateral medullary lamina and indirectly surround the rostrolateral border of the globus pallidus. The abundance of SP-, L-Enk-, neuropeptide Y-, CCK-, dopamine- and serotonin-positive fibers and terminal-like structures with a few positive fusiform neurons accumulating at the caudomedial border of the putamen obviously distinguishes this zone from the rest of neostriatum and globus pallidus. The acetylcholinesterase (AChE) positive and nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) containing fusiform neurons are distinctly visualized in the same zone. The morphological figure and the location of these neurons, and the histochemical and immunohistochemical characteristics of this area coincide well with those of the MrD in the rat and cat striatum. This study thus convincingly identifies the existence of the MrD in the monkey neostriatum. It is fairly asserted that the MrD is a universal structure in the mammalian brain.
Similar content being viewed by others
REFFERENCES
Shu, S. Y., Penny, G. R., and Peterson, G. M. 1988. The “Marginal Division”: a new subdivision in the neostriatum of the rat. J. Chem. Neuroanatomy 1:147–163.
Shu, S. Y., McGinty, J. F., and Peterson, G. M. 1990. High density of zinc-containing and dynorphin B-and substance P-immunoreactive terminals in the marginal division of the rat striatum. Brain Res. Bull. 24:2201–2205.
Bao, X. M. and Shu, S.Y. 1997. Distribution of neurotensin and somatostatin immunoreactivity in the marginal division of the rat striatum. Chinese J. Histochem. Cytochem. 6(6):1–5.
Bao, X. M. and Shu, S. Y. 1997. Distribution of Substance P-, Leu-enkephalin-, Cholecystokinin-immunoreactivity in the marginal division of the rat striatum. Chinese J. Neuroanat. 13(2): 107–110.
Bao, X. M., Shu, S. Y., and Li, S. X. 1993. The afferent projection in the marginal division of the rat striatum-Study on the WGA-HRP tracing with the anterograde or retrograde tract. Chinese J. of Neuroanat. 9(1):93–96.
Shu, S. Y., Bao, X. M., Li, S. X., and Xu, Z. W. 1993. Immuno-histochemical characteristics of afferent projection neurons in the marginal division of the rat striatum. Chinese J. of Anatomy 16(6):509–512.
Bao, X. M., Shu, S. Y., Niu, D. And Xu, Z. W. 1998. Distribution of substance P, Leu-enkephalin, neuropeptide Y and NADPH-d reactivities in the marginal division of the cat striatum. Chinese J. Neurosci. 14 (4):213–217.
Schoen, S. W. and Graybiel, A. M. 1993. Species-specific patterns of glycoprotein expression in the developing rodent caudoputamen: association of 5'-nucleotidase activity with dopamine islands and striosomes in rat, but with extrastriosomal matrix in mouse. J. Comp. Neurol. 333:578–596.
Heimer, L. and Alheid, G. F. 1991. Piecing together the puzzle of basal forebrain anatomy. Pages 1–42. in Napier, T. C., Kalivas, P. W. and Hanin, I. (eds), The Basal Forebrain. Plenum Press, New York.
Heimer, L., Zahm, D. S., and Alheid, G. F. 1995. Basal Ganglia. Pages 579–628. in Paxinos, G. (ed), The Rat Nervous System. Academic Press, New York.
Talley, E. M., Rosin, D. L., Lee, A., Guyenet, P. G., and Lynch, K. R. 1996. Distribution of Alpha 2A-adrenergic Receptor like immunoreactivity in the rat central nervous system. J. Comp. Neurol. 372(1):111–134.
Chudler, E. H., Sugiyama, K., and Dong, W. K. 1993. Nociceptive responses in the neostriatum and globus pallidus of the anesthetized rat. J. Neurophysiol. 69(5):1890–1903.
Chudler, E. H. and Dong, W. K. 1995. The role of the basal ganglia in nociception and pain. Pain 60:3–38.
Lavoie, B. and Parent, A. 1994. Pedunculopointine nucleus in the squirrel monkey: projection to the basal ganglia as revealed by anterograde tract-tracing methods. J. Comp. Neurol. 344(2):210–231.
Shu, S. Y., Ju, G., and Fan, L. 1988b. The glucose oxidase-DAB-nickel method in the peroxidase histochemistry of the nervous system. Neurosci. Lett. 85:169–171.
Nauta, W. J. H. and Domesick, V. B. 1984. Afferent and efferent relationships of the basal ganglia. Pages 3–33, in Nauta, W. J. H. and Domesick, V. B. (eds), Functions of the basal ganglia, Ciba Foundation Symposium 107, Pitman, London.
Graybiel, A. M. and Ragsdale, C. W. Jr. 1983. Biochemical anatomy of striatum. in Emson, P. C. (ed), Chemical Neuro-anatomy, Raven Press, New York.
Decavel, C., Lescaudron, L., Mons, N., and Calas, A. 1987. First visualization of dopaminergic neurons with a monoclonal antibody to dopamine: a light and electron microscopic study. J. Histochem. Cytochem. 35(11):1245–51.
Lorenzini, C. A., Baldi, E., Bucherelli, C., and Tassoni, G., 1995. Time-dependent deficits of rat's memory consolidation induced by trodotoxin injections into the caudo-putamen, nucleus accumbens, and globus pallidus. Neurobiol. Learn. Mem. 63 (1):87–93.
Noda, Y., Yamada, K., and Nabeshima, T. 1997. Role of nitric oxide in the effect of aging on spatial memory in rats. Behav. Brain Res. 83(1–2):153–158.
Yamada, K., Noda, Y., Komori, Y., Sugihara, H., Hasegawa, T., and Nabeshima, T. 1996. Reduction in the number of NADPH-diaphorase-positive cells in the cerebral cortex and striatum in aged rats. Neurosci. Res. 24(4):393–402.
Hasenohrl, R. U., Frisch, C., and Huston, J. P. 1998. Evidence for anatomical specificity for the reinforcing effects of SP in the nucleus basalis magnocellularis. Neuroreport 9 (1):7–10.
Ishizuk, N., Weber, J., and Amaral, D. G. 1990. Organization of intrahippocampal projections originating from CA3 pyramidal cells in the rat. J. Comp. Neurol. 295:580–623.
Shu, S. Y., Bao, R., Bao, X. M., Zheng, Z. C., and Niu, D. B. 1998. Synaptic Connection between the efferent projection from the marginal division of the striatum and the Meynert's basal nucleus and its relationship to learning and memory behavior of the rat. Chinese J. Histochem. Cytochem. 7(1):1–11.
Orgren, S. O. 1985. Central serotonin neurons in avoidence learning: interactions with noradrenaline and dopamine neurons. Pharmacol. Biochem. Behav. 23 (1):107–123.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shu, S.Y., Bao, X.M., Zhang, C. et al. A New Subdivision, Marginal Division, in the Neostriatum of the Monkey Brain. Neurochem Res 25, 231–237 (2000). https://doi.org/10.1023/A:1007523520251
Issue Date:
DOI: https://doi.org/10.1023/A:1007523520251