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Pulmonary surfactant: A surface chemistry viewpoint

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Abstract

In this paper, we attempt to review and evaluate pulmonary surfactant research from what is essentially a surface chemistry viewpoint. The physiological importance of the system underlies the discussion, but this is coupled with the surface chemical consideration of pulmonary surfactant as a complex multicomponent system of soluble and insoluble surfactants at a liquid-air interface. The systemin vivo is at a constant temperature (37°C) and an essentially constant bulk pressure, but is subject to large variations in surface cycling frequency and in maximum and minimum surface area. In this context, then, the present level of knowledge of the system is discussed, and areas of uncertainty or conflict which require further study are isolated. In addition, experimental or analytical approaches useful for future surface studies are given wherever possible.

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References

  • Abrams, M. E. Isolation and quantitative estimation of pulmonary surface-active lipoprotein.Journal of Applied Physiology, 1966,21, 718–720.

    CAS  PubMed  Google Scholar 

  • Adamson, A. W.Physical chemistry of surfaces. New York: Interscience, 1967, 2nd Ed.

    Google Scholar 

  • Adamson, I. Y. R., Bowden, D. H., and Wyatt, J. B. Oxygen poisoning studies in mice: Ultrastructural and surfactant studies during exposure and recovery.Archives of Pathology, 1970,90, 463–472.

    CAS  PubMed  Google Scholar 

  • Adamson, I. Y. R., and Bowden, D. H. The surface complexes of the lung: A cytochemical partition of phospholipid surfactant and mucopolysaccharide.American Journal of Pathology, 1970,61, 359–368.

    CAS  PubMed  Google Scholar 

  • Adamson, I. Y. R., and Bowden, D. H. Sialomucin and pulmonary cell injury.Archives of Pathology, 1971,92, 273–278.

    CAS  PubMed  Google Scholar 

  • Alarie, Y., and Robillard, E. Modifications of pressure-volume curves in rat lungs after inhalation of surface active extracts and agents.Physiologist, 1963,6, 128 (Abstract).

    Google Scholar 

  • Alarie, Y., Choby, M. A., and Poel, W. E. Alveolar instability following administration of fluorocarbon.Toxicology and Applied Pharmacology, 1972,22, 306 (Abstract).

    Google Scholar 

  • Alarie, Y., Barrow, C., Choby, M. A., and Quealy, J. F. Pulmonary atelectasis following administration of halogenated hydrocarbons.Toxicology and Applied Pharmacology, 1975,31, 233–242.

    Article  CAS  PubMed  Google Scholar 

  • Archer, R. J., and La Mer, V. K. The rate of evaporation of water through fatty acid monolayers.Journal of Physical Chemistry, 1955,59, 200–208.

    Article  CAS  Google Scholar 

  • Avery, M. E., and Mead, J. Surface properties in relation to atelectasis and hyaline membrane disease,Journal of Diseases of Children, 1959,97, 517–523.

    CAS  PubMed  Google Scholar 

  • Avery, M. E., Wang, N., and Taeusch, H. W. Jr. The lung of the newborn infant.Scientific American, 1973,228, 75–85.

    Google Scholar 

  • Bachofen, H., Hildebrandt, J., and Bachofen, M. Pressure-volume curves of air-and liquid-filled excised lungs—surface tension in situ.Journal of Applied Physiology, 1970,29, 422–431.

    CAS  PubMed  Google Scholar 

  • Balchum, O. J., O'Brien, J. S., and Goldstein, B. D. Ozone and unsaturated fatty acids.Archives of Environmental Health, 1971,22, 32–34.

    CAS  PubMed  Google Scholar 

  • Beckman, D. L., and Houlihan, R. T. Hyperbaric oxygen and alveolar surfactants.Aerospace Medicine, 1973,44, 422–424.

    CAS  PubMed  Google Scholar 

  • Berg, J. C. Some properties of dipalmitoyl lecithin monolayers and their relationship to lung behavior. Paper No. 36a, 64th Annual AIChE Meeting, San Francisco, Calif., Nov. 29, 1971.

  • Bienkowski, R., and Skolnick, M. Dynamic behavior of surfactant films.Journal of Colloid and Interface Science, 1972,39, 323–330.

    Article  CAS  Google Scholar 

  • Bienkowski, R., and Skolnick, M. On the calculation of surface tension in lungs from pressurevolume data.Journal of Colloid and Interface Science, 1974,48, 350–351.

    Article  Google Scholar 

  • Bils, R. F. Effects of nitrogen dioxide and ozone on monkey lung ultrastructure.Pneumonologie, 1974,150, 99–111.

    Article  CAS  PubMed  Google Scholar 

  • Blank, M., and Roughton, F. J. W. The permeability of monolayers to carbon dioxide.Transactions of the Faraday Society, 1960,56, 1832–1841.

    Article  CAS  Google Scholar 

  • Blank, M. The permeability of monolayers to several gases. In V. K. la Mer (Ed.),Retardation of evaporation by monolayers. New York: Academic Press, 1962.

    Google Scholar 

  • Blank, M., Goldstein, A. B., and Lee, B. B. The surface properties of lung extract.Journal of Colloid and Interface Science, 1969,29, 148–154.

    CAS  PubMed  Google Scholar 

  • Blank, M., and Lee, B. B. Problems in the study of spread films of lung extract.Journal of Colloid and Interface Science, 1971,36, 151–152.

    Article  Google Scholar 

  • Boecker, B. B., Muggenburg, B. A., McClellan, R. O., Clarkson, S. P., Mares, J. F., and Benjamin, S. A. Removal of144Ce in fused clay particles from beagle dog lung by bronchopulmonary lavage.Health Physics, 1974,26, 505–517.

    CAS  PubMed  Google Scholar 

  • Bolande, R. P., and Marshall, H. K. The morphologic demonstration of an alveolar lining layer and its relationship to pulmonary surfactant.American Journal of Pathology, 1964,45, 449–463.

    CAS  PubMed  Google Scholar 

  • Bondurant, S., and Smith, C. Effect of oxygen intoxication on the surface characteristics of lung extracts.Physiologist, 1962,5, 111–114.

    Google Scholar 

  • Bondurant, S. The alveolar lining: A method of extraction; the surface tension lowering effect of cigarette smoke.Journal of Clinical Investigation, 1960,39, 973–974.

    Google Scholar 

  • Bracco, M., Curti, P. C., and Camerota, G. Alterations of the pulmonary static mechanical properties and of the tensioactive substance of the alveolar lining caused by ethyl alcohol.Annali dell Instituto Carlo Forlanini, 1969,29, 273–280.

    CAS  Google Scholar 

  • Brashear, R. E., and Christian, J. C. Endobronchial lavage phospholipids and protein in rats protected from oxygen toxicity and hypoxia pretreatment.Metabolism: Clinical and Experimental, 1973,22, 1345–1348.

    CAS  Google Scholar 

  • Brooks, R. E. Lung surfactant: An alternate hypothesis.American Review of Respiratory Disease, 1971,104, 585–586.

    CAS  PubMed  Google Scholar 

  • Brown, E. A. B. The localization, metabolism, and effects of drugs and toxicants in lung.Drug Metabolism Reviews, 1974,3, 33–87.

    CAS  PubMed  Google Scholar 

  • Brown, E. S. Lung area from surface tension effects.Proceedings of the Society of Experimental Biological Medicine, 1957,95, 168–170.

    CAS  Google Scholar 

  • Bunnell, J. B., and Shannon, D. C. Lecithin aerosol therapy for respiratory distress syndrome. Paper No. 9.7, 27th Annual AEMB Meeting, Philadelphia, Pa., Oct. 1974.

  • Burton, R. A., and Mannheimer, R. J. Analysis and apparatus for surface rheological measurements. In R. F. Gould (Ed.),Advances in chemistry series 63—ordered fluids and liquid crystals. Washington, D.C.: American Chemical Society, 1967.

    Google Scholar 

  • Cadenhead, D. A., and Demchak, R. J. A new representation of condensation effects in mixed monolayers.Journal of Colloid and Interface Science, 1969,30, 76–80.

    Article  CAS  PubMed  Google Scholar 

  • Cadenhead, D. A., and Phillips, M. C. Molecular interactions in mixed monolayers. In R. F. Gould (Ed.),Advances in chemistry series 84 — molecular association in biological and related systems. Washington, D.C.: American Chemical Society, 1968.

    Google Scholar 

  • Cadenhead, D. A. Monolayers of synthetic phospholipids. In J. F. Danielli, A. C. Riddiford, and M. D. Rosenberg (Eds.),Recent progress in surface science. New York: Academic Press, 1970. Vol. 3.

    Google Scholar 

  • Cadenhead, D. A., and Kellner, B. M. J. Some observations on monolayer spreading solvents with special reference to phospholipid monolayers.Journal of Colloid and Interface Science, 1974,49, 143–145.

    CAS  Google Scholar 

  • Caldwell, P. R. B., Giammona, S. T., Lee, W. L., Jr., and Bondurant, S. Effect of oxygen breathing at one atmosphere on pulmonary surfactant in dogs.Clinical Research, 1963,11, 301 (Abstract).

    Google Scholar 

  • Callas, G. A new fixation technique for the electron microscopic study of pulmonary surfactant.The Anatomical Record, 1974,180, 457–464.

    Article  CAS  PubMed  Google Scholar 

  • Chapman, D., Owens, N. F., and Walker, D. A. Physical studies of phospholipids II. Monolayer studies of some synthetic 2,3-diacyl-dl-phosphatidylethanolamines and phosphatidylcholines containing trans double bonds.Biochimica et Biophysica Acta 1966,120, 148–155.

    CAS  PubMed  Google Scholar 

  • Chapman, D., Owens, N. F., Phillips, M. C., and Walker, D. A. Mixed monolayers of phospholipids and cholesterol,Biochimica et Biophysica Acta, 1969,183, 458–465.

    CAS  PubMed  Google Scholar 

  • Chase, W. H. The surface membrane of pulmonary alveolar walls.Experimental Cell Research, 1959,18, 15–28.

    Article  CAS  PubMed  Google Scholar 

  • Chu, J., Clements, J. A., Cotton, E. K., Klaus, M. H., Sweet, A. Y., and Tooley, W. H. Neonatal pulmonary ischemia. I. Clinical and physiological studies.Pediatrics, 1967,40, 709–782.

    PubMed  Google Scholar 

  • Clark, J. M., and Lambertsen, C. J. Pulmonary oxygen toxicity: A review.Pharmacological Reviews, 1971,23, 37–133.

    CAS  PubMed  Google Scholar 

  • Clements, J. A. Surface tension of lung extracts.Proceedings of the Society of Experimental Biological Medicine, 1957,95, 170–172.

    CAS  Google Scholar 

  • Clements, J. A., Brown, E. S., and Johnson, R. P. Pulmonary surface tension and the mucus lining of the lungs: Some theoretical considerations.Journal of Applied Physiology, 1958,12, 262–268.

    CAS  PubMed  Google Scholar 

  • Clements, J. A. and Tierney, D. F. Alveolar instability associated with altered surface tension. In W. O. Fenn and H. Rann (Eds.),Handbook of physiology, respiration. Baltimore: Waverly Press, 1965, Vol. 2, Sect. 3.

    Google Scholar 

  • Clements, J. A. Pulmonary surfactant.American Review of Respiratory Disease, 1970,101, 984–990.

    CAS  PubMed  Google Scholar 

  • Clements, J. A., Nellenbogen, J., and Trahan, H. J. Pulmonary surfactant and evolution of the lungs.Science, 1970,169, 603–604.

    CAS  PubMed  Google Scholar 

  • Clements, J. A. Lung surfactant: An alternate hypothesis.American Review of Respiratory Disease, 1971,104, 609.

    CAS  PubMed  Google Scholar 

  • Clements, J. A. Smoking and pulmonary surfactant.New England Journal of Medicine, 1972,286, 261–262.

    CAS  PubMed  Google Scholar 

  • Colacicco, G. Applications of monolayer techniques to biological systems: Symptoms of specific lipid-protein interactions.Journal of Colloid and Interface Science, 1969,29, 345–364.

    Article  CAS  PubMed  Google Scholar 

  • Colacicco, G. Lipid monolayers: Surface potential of dipalmitoyllecithin with regard to ion sorption and CA 2+ binding.Biochimica et Biophysica Acta, 1971,266, 313–319.

    Google Scholar 

  • Colacicco, G. Lipid monolayers: Ionic impurities and their influence on the surface potentials of neutral phospholipids.Chemistry and Physics of Lipids, 1973,10, 66–72.

    Article  CAS  Google Scholar 

  • Colacicco, G., Buckelew, A. R., Jr., and Scarpelli, E. M. Protein and lipid-protein fractions of lung washings: chemical characterization.Journal of Applied Physiology, 1973,34, 743–749.

    CAS  PubMed  Google Scholar 

  • Colacicco, G., Valdivia, E., and Scarpelli, E. M. Zero surface tension: A criterion for pulmonary surfactant.Federation Proceedings Abstracts, 1974,33, 345.

    Google Scholar 

  • Cook, W. A., and Webb, W. R. Surfactant in chronic smokers.Annals of Thoracic Surgery, 1966,2, 327–333.

    CAS  PubMed  Google Scholar 

  • Cosmi, E. V., Condorelli, S., and Scarpelli, E. M. Pulmonary surfactants in anesthesis and resuscitation.Acta Anesthesiologica, 1970,31, 95–127.

    Google Scholar 

  • Cottrell, T. X., Levine, O. R., Senior, R. M., Weiner, J., Spiro, D., and Fishman, A. P. Electron microscopic alterations at the alveolar level in pulmonary edema.Circulation Research, 1967,21, 783–797.

    CAS  PubMed  Google Scholar 

  • Cross, C. E. The granular type II pheumonocyte and lung antioxidant defense.Annals of Internal Medicine, 1974,80, 409–411.

    CAS  PubMed  Google Scholar 

  • Cunningham, A. L., and Hurley, J. V.. Alpha-naphthyl-thiourea-induced pulmonary oedema in the rat: A topographical and electron-microscopic study.Journal of Pathology, 1972,106, 25–35.

    Article  CAS  PubMed  Google Scholar 

  • Curti, P., and Bracco, M. Activity of anesthetics on pulmonary static mechanical properties and on the tensioactive substance of the alveolar lining caused by ethyl alcohol.Annali dell Instituto Carlo Forlanini, 1969,29, 239–251.

    Google Scholar 

  • Curti, P. C., and Camerota, G. Effect of NA-872 on alterations of the alveolar surfactant produced by ultrasonic nebulization of water.Aerztliche Forschung, 1972,26, 203–206.

    CAS  Google Scholar 

  • Dalldorf, F. G., Beall, F. A., Krigman, M. R., Goyer, R. A., and Livingston, H. L. Transcellular permeability and thrombosis of capillaries in anthrax toxaemia.Laboratory Investigation 1969,21, 42–51.

    Google Scholar 

  • Darke, A., Finer, E. G., Flook, A. G., and Phillips, M. C. Nuclear magnetic resonance study of lecithin-cholesterol interactions.Journal of Molecular Biology, 1972,63, 265–279.

    Article  CAS  PubMed  Google Scholar 

  • Davies, J. T., and Rideal, E. K. Interfacial phenomena. New York: Academic Press, 1963. 2nd ed.

    Google Scholar 

  • Davis, S. H. and Horn, L. W. Studies on lung surfactant. Paper No. 62, 66th Annual AIChE meeting, Philadelphia, Pa., Nov. 1973.

  • Davis, S. H. A mechanism for lung surfactant transport. Paper in session F4, Biomedical Engineering I, AIChE-GVC Meeting, Munich, Germany, Sept. 1974.

  • Demel, R. A., Van Deenen, L. L. M., and Pethica, B. A. Monolayer interactions of phospholipids and cholesterol.Biochimica et Biophysica Acta, 1967,135, 11–19.

    CAS  Google Scholar 

  • Demel, R. A., Geurts Van Kessel, W. S. M., Van Deenen, L. L. M. The properties of polyunsaturated lecithins in monolayers and liposomes and the interactions of these lecithins with cholesterol.Biochimica et Biophysica Acta, 1972a,266, 26–40.

    CAS  Google Scholar 

  • Demel, R. A., Bruckdorfer, K. R., and Van Deenen, L. L. M. Structural requirements of sterols for the interaction with lecithin at the air-water interface.Biochimica et Biophysica Acta, 1972b,255, 311–320.

    CAS  PubMed  Google Scholar 

  • Eriksson, J. C. Thermodynamics of surface-phase systems VI. On the rigorous thermodynamics of insoluble surface films.Journal of Colloid and Interface Science, 1971,37, 659–667.

    Article  CAS  Google Scholar 

  • Evans, J. A., Hamilton, R. W., Jr., Kuenzig, M. C., and Peltier, L. C. Effects of anesthetic agents on surface properties of dipalmitoyl lecithin.Anesthesie, Analgesie, Reanimation, 1966,45, 285–289.

    CAS  Google Scholar 

  • Felmeister, A., Amanat, M., and Weiner, N. D. Interaction of nitrogen dioxide-olefin gas mixtures with lecithin monomolecular films.Environmental Science and Technology, 1968,2, 40–43.

    Article  CAS  Google Scholar 

  • Finer, E. G., and Phillips, M. C. Factors affecting molecular packing in mixed lipid monolayers and bilayers.Chemistry and Physics of lipids, 1973,10, 237–252.

    Article  CAS  Google Scholar 

  • Finley, T. N., and Ladman, A. J. Low yield of pulmonary surfactant in cigarette smokers.New England Journal of Medicine, 1972,286, 223–227.

    CAS  PubMed  Google Scholar 

  • Fisher, M. H., Wilson, M. F., and Weber, K. C. Determination of alveolar surface area and tension fromin situ pressure-volume data.Respiration Physiology, 1970.,10, 159–171.

    Article  CAS  PubMed  Google Scholar 

  • Frosolono, M. F., Charms, B. L., Pawlowski, R., and Slivka, S. Isolation, characterization, and surface chemistry of a surface-active fraction from dog lung.Journal of Lipid Research, 1970,11, 439–457.

    CAS  PubMed  Google Scholar 

  • Gabor, S., Frits, T., Bohm, B., Anca, Z., Coldea, V., and Zugravu, E. Alveolar surface forces and composition of the pulmonary surfactant in experimental silicosis.Internationales Archiv fur Arbeitsmedizin, 1971,28, 312–320.

    CAS  PubMed  Google Scholar 

  • Gaines, G. L., Jr. Insoluble monolayers at liquid-gas interfaces. New York: Interscience, 1966.

    Google Scholar 

  • Galdston, M., and Shah, D. O. Surface properties and hysteresis of dipalmitoyl lecithin in relation to the alveolar lining layer.Biochimica et Biophysica Acta, 1967,137, 255–263.

    CAS  PubMed  Google Scholar 

  • Galdston, M., Shah, D. O., and Shinowara, G. Y. Isolation and characterization of a lung lipoprotein surfactant.Journal of Colloid and Interface Science, 1969,29, 319–334.

    Article  CAS  PubMed  Google Scholar 

  • Gershfeld, N. L. Intermolecular energies in condensed, lipid monolayers on water.Journal of Colloid and Interface Science, 1970,32, 167–172.

    Article  CAS  PubMed  Google Scholar 

  • Gershfeld, N. L. Film balance and the evaluation of intermolecular energies in monolayers. In R. J. Good, R. R. Stromberg, and R. L. Patrick (Eds.),Techniques of surface colloid chemistry and physics. New York: Dekker, 1972.

    Google Scholar 

  • Gershfeld, N. L., and Pagano, R. E. Physical chemistry of lipid films at the air-water interface. I. Intermolecular energies in single-component lipid films.Journal of Physical Chemistry, 1972a,76, 1231–1237.

    CAS  PubMed  Google Scholar 

  • Gershfeld, N. L., and Pagano, R. E. Physical chemistry of Lipid films at the air-water interface. III. The condensing effect of cholesterol. A critical examination of mixed-film studies.Journal of Physical Chemistry, 1972b,76, 1244–1249.

    CAS  PubMed  Google Scholar 

  • Ghosh, D., Lyman, R. L., and Tinoco, J. Behavior of specific natural lecithins and cholesterol at the air-water interface.Chemistry and Physics of lipids, 1971,7, 173–184.

    Article  CAS  PubMed  Google Scholar 

  • Ghosh, D. and Tinoco, J. Monolayer interactions of individual lecithins with natural sterols.Biochimica et Biophysica Acta, 1972,266, 41–49.

    CAS  PubMed  Google Scholar 

  • Giammona, S. T., Kerner, D., and Bondurant, S. Effect of oxygen breathing at atmospheric pressure on pulmonary surfactant.Journal of Applied Physiology, 1965,20, 855–858.

    CAS  PubMed  Google Scholar 

  • Giammona, S. T. Effects of furniture polish on pulmonary surfactant.American Journal of Diseases in Children, 1967,113, 658–663.

    CAS  Google Scholar 

  • Giammona, S. T., Tocci, P., and Webb, W. R. Effects of cigarette smoke on incorporation of radioisotopically labeled palmitic acid into pulmonary surfactant and on surface activity of canine lung extracts.American Review of Respiratory Diseases, 1971,104, 358–367.

    CAS  Google Scholar 

  • Gil, J. Effect of tricomplex fixation on lung tissue.Journal of Ultrastructure Research, 1972,40, 122–131.

    Article  CAS  PubMed  Google Scholar 

  • Groniowski, J., and Biczyskowa, W. Structure of the alveolar lining film of the lungs.Nature, 1964,204, 745–747.

    CAS  PubMed  Google Scholar 

  • Groniowski, J., and Biczyskowa, W. The extraneous coat of lung alveoli.Laboratory Investigation, 1969,20, 430–436.

    CAS  PubMed  Google Scholar 

  • Grünspan, M., Antweiler, H., and Dehnen, W. Effect of silica on phospholipids in the rat lung.British Journal of Industrial Medicine, 1973,30, 74–77.

    PubMed  Google Scholar 

  • Guyton, A. C. Interstitial fluid pressure-volume relationships in their regulation. In C. E. W. Wolstenholme and J. Knight (Eds.),Circulatory and respiratory mass transport. Boston: Little, Brown, 1969.

    Google Scholar 

  • Harkins, W. D., and Anderson, T. F. I. A simple accurate film balance of the vertical type for biological and chemical work, and a theoretical and experimental comparison with the horizontal type. II. Tight packing of a monolayer by ions.Journal of the American Chemical Society, 1937,59, 2189–2197.

    Article  CAS  Google Scholar 

  • Hayashi, M., Muramatsu, T., and Hara, I. Surface properties of synthetic phospholipidsBiochimica et Biophysica Acta, 1972,255, 98–106.

    CAS  PubMed  Google Scholar 

  • Hayes, J. A., and Shiga, A. Ultrastructural changes in pulmonary oedema produced experimentally with ammonium sulfate.Journal of Pathology, 1970,100, 281–286.

    Article  CAS  PubMed  Google Scholar 

  • Heppleston, A. G., Wright, N. A., and Stewart, J. A. Experimental alveolar lipoproteinosis following the inhalation of silica.Journal of Pathology, 1970,101, 293–307.

    Article  CAS  PubMed  Google Scholar 

  • Heppleston, A. G., and Young, A. E. Alveolar lipo-proteinosis: An ultrastructural comparison of the experimental and human forms.Journal of Pathology, 1972,107, 107–117.

    Article  CAS  PubMed  Google Scholar 

  • Heppleston, A. G., Fletcher, K. and Wyatt, I. Abnormalities of lung lipids following inhaliation of quartz.Experientia, 1972,28, 938–939.

    Article  CAS  PubMed  Google Scholar 

  • Heppleston, A. G., Fletcher, K., and Wyatt, I. Changes in the composition of lung lipids and the “turnover” of dipalmitoyl lecithin in experimental alveolar lipo-proteinosis induced by inhaled quartz.British Journal of Experimental Pathology, 1974,55, 384–395.

    CAS  PubMed  Google Scholar 

  • Horie, T., and Hildebrandt, J. Dynamic compliance, limit cycles, and static equilibria of excised cat lung.Journal of Applied Physiology, 1971,31, 423–430.

    CAS  PubMed  Google Scholar 

  • Horn, L. W., and Davis, S. H. Some studies of surface tension hysteresis. Paper in session F2, Biochemical Engineering I, AIChE-GVC meeting, Munich, Germany, Sept. 1974.

  • Hurst, D. J., Kilburn, K. H., and Lynn, W. S. Isolation and surface activity of soluble alveolar components.Repiration Physiology 1973,17, 72–80.

    CAS  Google Scholar 

  • Jalowayski, A. A., and Giammona, S. T. The interaction of bacteria with pulmonary surfactant.American Review of Respiratory Diseases, 1972,105, 236–241.

    CAS  Google Scholar 

  • Joly, M. Surface viscosity. In: J. F. Danielli, K. G. A. Pankhurst, and A. C. Riddiford (Eds.)Recent progress in surface science. New York: Academic Press, 1964, Vol. 1.

    Google Scholar 

  • Joos, P. Cholesterol as a liquifier in phospholipid membranes studied by surface viscosity measurements of mixed monolayers.Chemistry and Physics of Lipids, 1970,4, 162–168.

    Article  CAS  PubMed  Google Scholar 

  • Kahana, L. M., and Aronovitch, M. Effect of sulfur dioxide on surface properties of the lungs.American Review of Respiratory Disease, 1966,94, 201–207.

    CAS  PubMed  Google Scholar 

  • Kanpanci, Y., Weibel, E. R., Kaplan, H. P., and Robinson, F. R. Pathogenesis and reversibility of the pulmonary lesions of oxygen toxicity in monkeys. II. Ultrastructural and morphometric studies.Laboratory Investigations, 1969,20, 101–118.

    Google Scholar 

  • Kikkawa, Y., Motoyama, E. K., and Gluck, L. Study of the lungs of fetal and newborn rabbits: Morphological, biochemical, and sulface-physical development.American Journal of Pathology, 1968,52, 177–210.

    CAS  PubMed  Google Scholar 

  • Kikkawa, Y. Morphology of alveolar lining layer.Anatomical Record, 1970,167, 389–400.

    Article  CAS  PubMed  Google Scholar 

  • Kikkawa, Y., and Kaibara, M. The distribution of osmiophilic lamellae within the alveolar and bronchiolar walls of the mammalian lungs as revealed by osmium-ethanol treatment.American Journal of Anatomy, 1972,134, 203–220.

    Article  CAS  PubMed  Google Scholar 

  • Kilburn, K. H. Functional morphology of the distal lung.International Review of Cytology, 1974.37, 153–270.

    CAS  PubMed  Google Scholar 

  • Kilroe-Smith, T. A., and Oxenham, G. M. The effect of silica dust on the phospholipid metabolism of macrophages.Chemical and Biological Interactions, 1973,6, 367–373.

    CAS  Google Scholar 

  • Kimelberg, H. K., and Papahadjopoulos, D. Phospholipid-protein interactions: Membrane permeability correlated with monolayer “penetration.”Biochimica et Biophysica Acta, 1971,233, 805–809.

    CAS  PubMed  Google Scholar 

  • King, R. J., and Clements, J. A. Surface-active materials from dog lung. I. Method of isolation.American Journal of Physiology, 1972a,223, 707–714.

    CAS  PubMed  Google Scholar 

  • King, R. J., and Clements, J. A Surface-active materials from dog lung. II. Composition and physiological correlations.American Journal of Physiology, 1972b,223, 715–726.

    PubMed  Google Scholar 

  • King, R. J., and Clements, J. A. Surface-active materials from dog lung. III. Thermal analysis.American Journal of Physiology, 1972c,223, 727–733.

    CAS  PubMed  Google Scholar 

  • King, R. J., Klass, D. J., Gikas, E. G., and Clements, J. A. Isolation of apoproteins from canine surface-active material.American Journal of Physiology, 1973,224, 788–795.

    CAS  PubMed  Google Scholar 

  • King, R. J. The surfactant system of the lung.Federation Proceedings, 1974,33, 2238–2247.

    CAS  PubMed  Google Scholar 

  • Kistler, G. S., Caldwell, P. R. B., and Weibel, E. R. Development of fine structural damage to alveolar and capillary lining cells in oxygen-poisoned rat lungs.Journal of Cell Biology, 1967,32, 605–628.

    Article  CAS  PubMed  Google Scholar 

  • Klaus, M. H., Clements, J. A., and Havel, R. J. Composition of surface-active material isolated from beef lung.Proceedings of the National Academy of Sciences, 1961,47, 1858–1859.

    CAS  Google Scholar 

  • Kott, A. T., Gardner, J. W., Schechter, R. S., and DeGroot, W. The elasticity of pulmonary lung surfactant.Journal of Colloid and Interface Science, 1974,47, 265–266.

    Article  CAS  Google Scholar 

  • Ladányi, E., Zugravu, E., and Tomoaia, M. Electrochemical methods in surface-activity studies of lung surfactant.Internationales Archiv fur Arbeitsmedizin, 1974,33, 245–250.

    PubMed  Google Scholar 

  • Ladbrooke, B. D., Williams, R. M. and Chapman, D. Studies on lecithin-cholesterol-water interactions by differential scanning calorimetry and x-ray diffraction.Biochimica et Biophysica Acta, 1968,150, 333–340.

    CAS  PubMed  Google Scholar 

  • Langmuir, I. The constitution and fundamental properties of solids and liquids. II. Liquids.Journal of the American Chemical Society, 1917,39, 1848–1906.

    Article  CAS  Google Scholar 

  • Lempert, J., and Macklem, P. T. Effect of temperature on rabbit lung surfactant and pressure-volume hysteresis.Journal of Applied Physiology, 1971,31, 380–385.

    CAS  PubMed  Google Scholar 

  • Leroy, E. P., Liebner, E. J., and Jenski, R. J. The ultrastructure of canine alveoli after supervoltage irradiation of the thoracic. I. Lesions of the latent period.Laboratory Investigation, 1966,15, 1544–1558.

    CAS  PubMed  Google Scholar 

  • Liggins, G. C., and Howie, R. N. A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants.Pediatrics, 1972,50, 515–525.

    CAS  PubMed  Google Scholar 

  • Lim, B. Surface viscosity of dipalmitoyl-lecithin at the air-water interface. M.S. Thesis, University of Washington, 1971.

  • Lucassen-Reynders, E. H. A surface equation of state for mixed surfactant monolayers.Journal of Colloid and Interface Science, 1972,41, 156–167.

    CAS  Google Scholar 

  • Lucassen-Reynders, E. H. Interactions in mixed monolayers. I. Assessment of interaction between surfactants.Journal of Colloid and Interface Science, 1973a,42, 554–562.

    CAS  Google Scholar 

  • Lucassen-Reynders, E. H. Interactions in mixed monolayers. II. Effect on equilibrium, surface properties, with application to fatty acid soap solutions.Journal of Colloid and Interface Science, 1973b,42, 563–572.

    CAS  Google Scholar 

  • Lucassen-Reynders, E. H. Interactions in mixed monolayers. III. Effect on dynamic surface properties.Journal of Colloid and Interface Science, 1973c,42, 573–580.

    CAS  Google Scholar 

  • Lusted, D. Wilhelmy surface tension data in mixed-lipid cyclic film compression.Journal of Colloid and Interface Science, 1973,44, 72–78.

    Article  CAS  Google Scholar 

  • Macklem, P. T., and Murphy, B. The forces applied to the lung in health and disease.The American Journal of Medicine, 1974,57, 371–77.

    Article  CAS  PubMed  Google Scholar 

  • Macklin, C. C. Pulmonary sumps, dust accumulations, alveolar fluid and lymph vessels.Acta Anatomica, 1955,23, 1–33.

    CAS  PubMed  Google Scholar 

  • Mannheimer, R. J., and Schechter, R. S. An improved apparatus and analysis for surface-rheological measurements.Journal of Colloid and Interface Science, 1970a,32, 195–211.

    CAS  Google Scholar 

  • Mannheimer, R. J., and Schechter, R. S. An improved apparatus and analysis for surface rheological viscous-traction method.Journal of Colloid and Interface Science, 1970b,32, 225–241.

    Google Scholar 

  • Mead, J., Takashima, T., and Leith, L. Stress distribution in lungs: A model of pulmonary elasticity.Journal of Applied Physiology, 1970,28, 596–608.

    CAS  PubMed  Google Scholar 

  • Mendenhall, R. M., and Stokinger, H. E. Films from lung washings as a mechanism model for lung injury by ozone.Journal of Applied Physiology, 1962,17, 28–32.

    CAS  PubMed  Google Scholar 

  • Mendenhall, R. M., Sun, C. N., and Mendenhall, A. L., Jr. Lung alveolar surfactant and the Thomson-Marangoni effects.Respiration Physiology, 1967,2, 360–374.

    CAS  PubMed  Google Scholar 

  • Mendenhall, R. M. Surface spreading of lung alveolar surfactant.Respiration Physiology, 1972,16, 175–178.

    Article  CAS  PubMed  Google Scholar 

  • Miller, D., and Boudurant, S. Effects of cigarette smoke on the surface characteristics of lung extracts.American Review of Respiratory Disease, 1962,85, 692–696.

    CAS  PubMed  Google Scholar 

  • Miller, J. M., and Sproule, B. J. Acute effects of inhalation of cigarette smoke on mechanical properties of the lungs.American Review of Respiratory Disease, 1966,94, 721–726.

    CAS  PubMed  Google Scholar 

  • Miller, R. N., and Thomas, P. A. Pulmonary surfactant: Determinations from lung extracts of patients receiving diethyl ether or halothane.Anesthesiology, 1967,28, 1089–1093.

    CAS  PubMed  Google Scholar 

  • Modell, J. H., Giammona, S. T., and Alvarez, L. A. Effect of ultrasonic nebulized suspensions on pulmonary surfactant.Diseases of the Chest, 1966,50, 627–629.

    CAS  PubMed  Google Scholar 

  • Morgan, T. E., Finley, T. N., and Fialkow, H. Comparison of the composition and surface activity of “alveolar” and whole lung lipids in the dog.Biochimica et Biophysica Acta, 1965,106, 403–413.

    CAS  PubMed  Google Scholar 

  • Morgan, T. E. Pulmonary surfactant.New England Journal of Medicine, 1971,284, 1185–1193.

    CAS  PubMed  Google Scholar 

  • Morrow, P. E. Aerosol characterization and deposition.American Review of Respiratory Disease, 1974,110, 88–99.

    CAS  PubMed  Google Scholar 

  • Motomura, K. Thermodynamics of multicomponent, monolayers. I. General formulation.Journal of Colloid and Interface Science, 1974,48, 307–318.

    Google Scholar 

  • Motomura, K., Sekita, K., and Matuura, R. Thermodynamics of multicomponent monolayers. II. Phase transitions in two-component monolayers.Journal of Colloid and Interface Science, 1974,48, 319–326.

    CAS  Google Scholar 

  • Notter, R. H., and Berg, J. C. Transport resistance of dipalmitoyl and rat lung lecithin films.Journal of Colloid and Interface Science 1973,45, 421–424.

    Article  CAS  Google Scholar 

  • Obenour, R. A., Saltzman, H. A., Sieker H. O. and Green, J. L. Effects of surfactive-active aerosols and pulmonary congestion on lung compliance and resistance.Circulation 1963,28, 888–892.

    CAS  PubMed  Google Scholar 

  • Pagano, R. E., and Gershfeld, N. L. A millidyne film balance for measuring intermolecular energies in lipid films.Journal of Colloid and Interface Science, 1972a,41, 311–317.

    Article  CAS  Google Scholar 

  • Pagano, R. E., and Gershfeld, N. L. Physical chemistry of lipid films at the air-water interface. II. Binary lipid mixtures: The principles governing miscibility of lipids in surfaces.Journal of Physical Chemistry, 1972b,76, 1238–1243.

    Article  CAS  PubMed  Google Scholar 

  • Pankhurst, K. G. A. Molecular structure as revealed by electron microscopy.Journal of Physical Chemistry, 1955,59, 480.

    Article  CAS  Google Scholar 

  • Papahadjopoulos, D. Surface properties of acidic phospholipids: Interaction of monolayers and hydrated liquid crystals with uni-and bi-valent metal ions.Biochimica et Biophysica Acta, 1968,163, 240–254.

    CAS  PubMed  Google Scholar 

  • Pattle, R. E. Properties, function and origin of the alveolar lining layer.Nature, 1955,175, 1125–1126.

    CAS  PubMed  Google Scholar 

  • Pattle, R. E. Properties, function and origin of the alveolar lining layer.Proceedings of the Royal Society (London), Series B, 1958,148, 217–240.

    CAS  Google Scholar 

  • Pattle, R. E. Surface lining of lung alveoli.Physiological Reviews, 1965,45, 48–79.

    CAS  PubMed  Google Scholar 

  • Pattle, R. E., and Burgess, F. The lung lining film in some pathological conditions.Journal of Pathology and Bacteriology, 1961,82, 315–331.

    CAS  PubMed  Google Scholar 

  • Pawlowski, R., Frosolono, M. F., Charms, B. L., and Przybylski, R. Intra- and extracellular compartmentalization of the surface-active fraction in dog lung.Journal of Lipid Research, 1971,12, 538–544.

    CAS  PubMed  Google Scholar 

  • Pearson, J. T. The application of monolayer techniques to a study of protein-surfactant interaction. II. Interactions in adsorbed films at the air/water interface, and in oil-in-water emulsions.Journal of Colloid and Interface Science, 1968,27, 64–74.

    CAS  PubMed  Google Scholar 

  • Pearson, J. T., and Alexander, A. E. The application of monolayer techniques to a study of protein-surfactant interaction. I. Interactions in spread films at the air/water interface.Journal of Colloid and Interface Science, 1968,27, 53–63.

    CAS  PubMed  Google Scholar 

  • Pfleger, R. C., Wilson, A. J., Cuddihy, R. G., and McClellan, R. O. Bronchopulmonary lavage for removal of inhaled insoluble materials from the lung.Diseases of the Chest, 1969,56, 524–530.

    CAS  PubMed  Google Scholar 

  • Phillips, M. C., and Chapman, D. Monolayer characteristics of saturated 1,2-diacylphosphatidylcholines (lecithins) and phosphatidylethanolamines at the air-water interface.Biochimica et Biophysica Acta, 1968,163, 301–313.

    CAS  PubMed  Google Scholar 

  • Phillips, M. C., Ladbrooke, B. D., and Chapman, D. Molecular interactions in mixed lecithin systems.Biochimica et Biophysica Acta, 1970,196, 35–44.

    CAS  PubMed  Google Scholar 

  • Phillips, M. C., Finer, E. G., and Hauser, H. Differences between conformations of lecithin and phosphatidylethanolamine polar groups and their effects on interactions of phospholipid bilayer membranes.Biochimica et Biophysica Acta, 1972,290, 397–402.

    CAS  PubMed  Google Scholar 

  • Radford, E. P., Jr. Method for estimating respiratory surface area of mammalian lungs from their physical characteristics.Proceedings of the Society of Experimental Biological Medicine, 1954,87, 58–61.

    Google Scholar 

  • Ramirez-Rivera, J. Bronchopulmonary lavage: New techniques and observations.Diseases of the Chest 1966,50, 581–588.

    Google Scholar 

  • Rhoades, R. A. Effect of inhaled carbon on surface properties of rat lung.Life Sciences, 1972,11, 33–42.

    Article  CAS  Google Scholar 

  • Ries, H. E., Jr., and Kimball, W. A. Monolayer structure as revealed by electron microscopy.Journal of Physical Chemistry 1955,59, 94–95.

    CAS  Google Scholar 

  • Ries, H. E., Jr., and Kimball, W. A. Structure of fatty acid monolayers and a mechanism for collapse. In J. H. Schulman (Ed.),Proceedings of second international congress of surface activity. New York: Academic Press, 1957. Vol. 1.

    Google Scholar 

  • Ries, H. E., Jr., and Walker, D. C. Films of mixed horizontally and vertically oriented compounds.Journal of Colloid Science, 1961,16, 361–374.

    CAS  Google Scholar 

  • Robillard, E., and Alarie, Y. Static volume-pressure relations in gineau pig lungs after inhalation of aluminum or iron oxide particles and bronchodilator aerosols.Canadian Journal of Biochemistry, 1963,41, 461–468.

    CAS  Google Scholar 

  • Robillard, E., Alarie, Y., Paganuzzi, P., and Dautrebande, L. “Pressure-volume” curves obtained on isolated atelectatic rats' lung after short inhalations of various insoluble submicronic and submicroscopic particles.Archives Internationales de Pharmacodynamie et de Thérapie, 1964a,147, 219–228.

    Google Scholar 

  • Robillard, E., Alarie, Y., Dagenais-Perusse, P., Baril, E., and Guilbeault, A. Microaerosol administration of synthetic β-γ-dipalmitoyl-L α-lecithin in the respiratory distress syndrome: A preliminary report.Canadian Medical Association Journal, 1964b,90, 55–57.

    CAS  PubMed  Google Scholar 

  • Rosenberg, E., Alarie, Y., and Robillard, E., Effect of dust and aerosol inhalation on surface and tissue elasticity of rat lungs.Canadian Journal of Biochemistry and Physiology, 1962,40, 1359–1365.

    CAS  PubMed  Google Scholar 

  • Scarpelli, E. M., Gabbay, K. H., and Kochen, J. A. Lung surfactants, counterions and hysteresis.Science, 1965,148, 1607–1609.

    CAS  PubMed  Google Scholar 

  • Scarpelli, E. M., Clutario, B. C., and Taylor, F. A. Preliminary identification of the lung surfactant system.Journal of Applied Physiology, 1967,23, 880–886.

    CAS  PubMed  Google Scholar 

  • Scarpelli, E. M.The surfactant system of the lung. Philadelphia: Lea and Febiger, 1968.

    Google Scholar 

  • Scarpelli, E. M., and Colacicco, G. Absence of lipoprotein in pulmonary surfactants.Advances in Experimental Medicine and Biology, 1970,7, 275–286.

    CAS  Google Scholar 

  • Scarpelli, E. M., Chang, S. J., and Colacicco, G. A search for the surface-active pulmonary lipoprotein.American Review of Respiratory Disease, 1970,102, 285–289.

    CAS  PubMed  Google Scholar 

  • Scarpelli, E. M., Wolfson, D. R., and Colacicco, G. Protein and lipid-protein fractions of lung washings: immunological characterization.Journal of Applied Physiology, 1973,34, 750–753.

    CAS  PubMed  Google Scholar 

  • Schaefer, K. E., Avery, M. E., and Bensch, H. Time course of changes in surface tension and morphology of alveolar epithelial cells in CO2-induced hyaline membrane disease.Journal of Clinical Investigation, 1964,43, 2080–2093.

    CAS  PubMed  Google Scholar 

  • Shah, D. O., and Schulman, J. H. Binding of metal ions to monolayers of lecithins, plasmalogen, cardiolipin, and dicetyl phosphate.Journal of Lipid Research, 1965,6, 341–349.

    CAS  PubMed  Google Scholar 

  • Shah, D. O., and Schulman, J. H. Influence of calcium, cholesterol, and unsaturation on lecithin monolayers.Journal of Lipid Research, 1967a,8, 215–226.

    CAS  PubMed  Google Scholar 

  • Shah, D. O., and Schulman, J. H. The ionic structure of lecithin monolayers.Journal of Lipid Research, 1967b,8, 227–233.

    CAS  PubMed  Google Scholar 

  • Shah, D. O., and Schulman, J. H. Enzymic hydrolysis of various lecithin monolayers employing surface pressure and potential techniques.Journal of Colloid and Interface Science, 1967c,25, 107–119.

    Article  CAS  Google Scholar 

  • Shah, D. O., and Schulman, J. H. Influence of induced dipoles, metal ions, and cholesterol on the characteristics of phospholipid monolayers. In R. F. Gould (Ed.),Advances in chemistry series 84-molecular association in biological and related systems. Washington, D.C.: American Chemical Society, 1968.

    Google Scholar 

  • Shah, D. O. Surface chemistry of lipids.Advances in Lipid Research, 1970,8, 347–431.

    CAS  Google Scholar 

  • Shannon, D. C., Kazemi, H., Merrill, E. W., Smith, K. A., and Wong, P. S.-L. Restoration of volume-pressure curves with a lecithin fog.Journal of Applied Physiology, 1969,28, 470–473.

    Google Scholar 

  • Sheppard, E., Bronson, R. P., and Tcheurekdjian, N. Monolayer studies. II. Electron microscopy of normal paraffinic polar compounds.Journal of Colloid Science, 1965,20, 755–765.

    Article  CAS  Google Scholar 

  • Standish, M. M., and Pethica, B. A. Surface pressure and surface potential study of a synthetic phospholipid at the air/water interface.Transactions of the Faraday Society, 1968,64, 1113–1122.

    Article  CAS  Google Scholar 

  • Staub, N. C., Nagano, H., and Pearce, M. L. Pulmonary edema in dogs, especially the sequence of fluid accumulation in the lungs.Journal of Applied Physiology, 1967,22, 227–240.

    CAS  PubMed  Google Scholar 

  • Staub, N. C. The pathophysiology of pulmonary edema,Human Pathology, 1970,1, 419–432.

    CAS  PubMed  Google Scholar 

  • Steim, J. M., Redding, R. A., Hauck, C. T., and Stein, M. Isolation and characterization of lung surfactant.Biochemical and Biophysical Research Communications, 1969,34, 434–440.

    Article  CAS  PubMed  Google Scholar 

  • Stephens, R. J., Sloan, M. F., and Evan, M. J. Early response of lung to low levels of ozone,American Journal of Pathology, 1974,74, 31–59.

    CAS  PubMed  Google Scholar 

  • Stolz, C. Behavior of surface-active film in the pulmonary alveoli after volatile oil inhalation.Medizinische Welt, 1972,26, 1209–1211.

    CAS  PubMed  Google Scholar 

  • Storey, W. F. and Staub, N. C. Ventilation of terminal air units.Journal of Applied Physiology, 1962,17, 391–397.

    CAS  PubMed  Google Scholar 

  • Tabak, S., and Notter, R. H. Factors affecting pure and mixed films of pulmonary surfactant components.Federation Proceedings Abstracts, 1975,34, 426.

    Google Scholar 

  • Taylor, A. E., Gibson, W. H., Granger, H. J., and Guyton, A. C. The interaction between intracapillary and tissue forces in the overall regulation of interstitial fluid volume.Lymphology, 1973,6, 192–208.

    CAS  PubMed  Google Scholar 

  • Taylor, F. B., and Abrams, M. E. Effect of surface-active lipoprotein on clotting and fibrinolysis, and of fibrinogen on surface tension of surface active lipoprotein.American Journal of Medicine, 1966,40, 346–350.

    Article  CAS  Google Scholar 

  • Thomas, P. A. Observations from the respiratory history of 30 patients with normal pulmonary surfactant.Journal of Thoracic and Cardiovascular Surgery, 1966,52, 11–16.

    CAS  PubMed  Google Scholar 

  • Tierney, D. F. Lung metabolism and biochemistry.Annual Review of Physiology, 1974,36, 209–231.

    Article  CAS  Google Scholar 

  • Tinoco, J., and McIntosh, D. J. Interactions between cholesterol and lecithins in monolayers at the air-water interface.Chemistry and Physics of Lipids, 1970,4, 72–84.

    Article  CAS  Google Scholar 

  • Träuble, H., Eibl, H., and Sawada, H. Respiration: A critical phenomenon? Lipid phase transitions in the lung alveolar surfactant.Naturwissenschaften, 1974,61, 344–354.

    Article  PubMed  Google Scholar 

  • Turner, S. R., Litt, M., and Lynn, W. S. Protein adsorption to teflon: Effect on apparent molecular area of dipalmitoyl lecithin.Journal of Colloid and Interface Science, 1974,48, 100–104.

    Article  CAS  Google Scholar 

  • Turner, S. R., Litt, M., and Lynn, W. S. Permeation of water-vapor through lipid monolayers.Journal of Colloid and Interface Science, 1975,50, 181–193.

    Article  CAS  Google Scholar 

  • Untersee, P., Gil, J., and Weibel, E. R. Visualization of extracellular lining layer of lung alveoli by freeze-etching.Respiratory Physiology, 1971,13, 171–185.

    Article  CAS  Google Scholar 

  • Van Deenen, L. L. M., Houtsmuller, U. M. T., DeHaas, G. H., and Mulder, E.. Monomolecular layers of synthetic phosphatides.Journal of Pharmacy and Pharmacology, 1962,14, 429–444.

    PubMed  Google Scholar 

  • Vilallonga, F., Altschul, R., and Fernandez, M. S. Lipid-protein interaction at the air-water interface.Biochimica et Biophysica Acta, 1967,135, 406–415.

    CAS  PubMed  Google Scholar 

  • Vilallonga, F. Surface chemistry ofL-α-dipalmitoyl lecithin at the air-water interface.Biochimica et Biophysica Acta, 1968,163, 290–300.

    CAS  PubMed  Google Scholar 

  • Villee, C. A., Villee, D. B., and Zuckerman, J. (Eds.)Respiratory distress syndrome. New York: Academic Press, 1973.

    Google Scholar 

  • Von Neergaard, K. Neue auffassungen über einen grundbegriff der atemmechanik. Die retraktionskraft der lunge, abhängig von der oberflächen spannung in den alveolen.Zeitschrift Für Die Gesamte Experimentelle Medizin, 1929,66, 373–394.

    Google Scholar 

  • Watkins, J. C. The surface properties of pure phospholipids in relation to those of lung extracts.Biochemica et Biophysica Acta, 1968,152, 293–306.

    CAS  Google Scholar 

  • Webb, W. R., Cook, W. A., Lanius, J. W., and Shah, R. R. Cigarette smoke and surfactant.American Review of Respiratory Disease, 1967,95, 244–247.

    CAS  PubMed  Google Scholar 

  • Weibel, E. R. Morphometrics of the lung. In W. O. Fenn and H. Rahn (Eds.),Handbook of physiology-respiration. Washington, D.C.: American Physiological Society, 1964. Vol. 1, Sect. 3.

    Google Scholar 

  • Weibel, E. R., and Gil, J. Electron microscopic demonstration of an extracellular duplex lining layer of alveoli.Respiration Physiology, 1968,4, 42–57.

    Article  CAS  PubMed  Google Scholar 

  • Weibel, E. R., and Gil, J. Morphologie der alveolaroberfläche.Pneumonologie, 1971,144, 159–166.

    CAS  PubMed  Google Scholar 

  • Weiner, N. D., Amanat, M., and Felmeister, A. Monomolecular films as a model to study air pollutant-membrane interactions.Archives of Environmental Health, 1969,18, 636–640.

    CAS  PubMed  Google Scholar 

  • West, J. B. Respiratory physiology-the essentials. Baltimore: Williams and Wilkins, 1974.

    Google Scholar 

  • Woo, S. W., Berlin, D., and Hedley-White, J. Surfactant function and anesthetic agents.Journal of Applied Physiology, 1969,26, 571–577.

    CAS  PubMed  Google Scholar 

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  1. Department of Chemical Engineering, The Pennsylvania State University, 16802, University Park, Pennsylvania

    R. H. Notter

  2. Department of Radiation Biology and Biophysics, University of Rochester, School of Medicine and Dentistry, 14642, Rochester, New York

    P. E. Morrow

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Notter, R.H., Morrow, P.E. Pulmonary surfactant: A surface chemistry viewpoint. Ann Biomed Eng 3, 119–159 (1975). https://doi.org/10.1007/BF02363067

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