Abstract
It has been shown previously that the disodium salt of a new HMG-CoA reductase inhibitor (SQ-33600) is capable of existing as a number of hydrate species [1]. Three crystalline solid hydrates and one liquid crystalline phase have been identified, each having a definite stability over a defined range of humidity. These forms have been found to exhibit varying fluorescence properties in their respective solid states, with differences in bandshapes and intensities being noted for each. These spectral variations have been correlated with the known pseudopolymorphism of the compound.
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REFERENCES
K.R. Morris, D.E. Bugay, A.W. Newman, S.A. Ranadive, A.K. Singh, S.A. Varia, H.G. Brittain, and A.T.M. Serajuddin. “Characterization of Humidity-Dependent Changes in Crystal Properties of a New HMG-CoA Reductase Inhibitor in Support of its Dosage Form Development”. Int. J. Pharm. 108:195–206 (1994).
S.R. Byrn. Solid State Chemistry of Drugs. Academic Press, New York, 1982.
K.R. Morris and N. Rodriguez-Hornendo. “Hydrates”. In J. Swarbrick and J.G. Boylan (eds.), Encyclopedia of Pharmaceutical Technology, Marcel Dekker, New York, 1993, pp. 393–440.
G.G. Guilbault, Practical Fluorescence: Theory, Methods, and Techniques. Marcel Dekker, New York, 1973.
J.R. Lakowicz, Principles of Fluorescence Spectroscopy, Plenum Press, New York, 1983.
J.B. Birks, Photophysics of Aromatic Molecules. Wilen-Interscience, New York, 1970.
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Brittain, H.G., Ranadive, S.A. & Serajuddin, A.T.M. Effect of Humidity-Dependent Changes in Crystal Structure on the Solid-State Fluorescence Properties of a New HMG-CoA Reductase Inhibitor. Pharm Res 12, 556–559 (1995). https://doi.org/10.1023/A:1016206130213
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DOI: https://doi.org/10.1023/A:1016206130213