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Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse

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Somatic Cell and Molecular Genetics

Abstract

The mouse genes for the serine proteases trypsin (Try-1,chymotrypsin B (Ctrb),and elastase (Ela-1)were chromosomally assigned using Southern blot hybridization of mouse × Chinese hamster cell hybrid DNA. cDNA probes for the three genes were hybridized to cell hybrid DNA cleaved with BamHI or HindIII and the segregation of Try-1, Ctrb,and Ela-1was correlated with the segregation of mouse chromosomes. Try-1is located on chromosome 6, Ctrbis on chromosome 8, and Ela-1is on chromosome 15. The three genes fall into three syntenic groups that are conserved in the mouse and human genomes.

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Author notes

  1. N. K. Honey

    Present address: Department of Microbiology and Genetics, Massey University, Palmerston North, New Zealand

  2. C. Quinto

    Present address: Centro de Figacion de Nitrogeno, Cuernavaca, Mexico

  3. G. I. Bell

    Present address: Chiron Corporation, Emeryville, California

  4. S. L. Naylor

    Present address: Department of Cellular and Structural Biology, University of Texas Health Science Center, 78284, San Antonio, Texas

Authors and Affiliations

  1. Roswell Park Memorial Institute, Buffalo, New York

    N. K. Honey, A. Y. Sakaguchi & S. L. Naylor

  2. Oak Ridge National Laboratory, Oak Ridge, Tennessee

    P. A. Lalley

  3. University of California, San Francisco, California

    C. Quinto, C. Craik, G. I. Bell & W. J. Rutter

  4. University of Texas Health Science Center at Dallas, Texas

    R. J. MacDonald

Authors
  1. N. K. Honey
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  2. A. Y. Sakaguchi
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  3. P. A. Lalley
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  4. C. Quinto
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  5. R. J. MacDonald
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  6. C. Craik
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  7. G. I. Bell
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  8. W. J. Rutter
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  9. S. L. Naylor
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Additional information

Preliminary chromosomal assignments of trypsin, chymotrypsin B, and elastase have been made in abstract (1).

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Honey, N.K., Sakaguchi, A.Y., Lalley, P.A. et al. Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse. Somat Cell Mol Genet 10, 377–383 (1984). https://doi.org/10.1007/BF01535633

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  • DOI: https://doi.org/10.1007/BF01535633

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